Ordering Recommendation

Aid in determining the etiology of elevated total creatine kinase. Troponin I (0090613) or Troponin T (cTnT) 5th Generation (3001831) are the recommended tests for diagnosis and management of acute coronary syndrome. May aid in identifying the presence of macro creatine kinase.

Mnemonic

CKISO

Methodology

Quantitative Enzymatic Assay/Electrophoresis

Performed

Sun-Sat

Reported

2-3 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum Separator Tube (SST) or Plain Red.

Specimen Preparation

Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Frozen.

Unacceptable Conditions

Specimens preserved in citrate, EDTA, fluoride, heparin, or iodoacetate. Grossly hemolyzed specimens.

Remarks
Stability

After separation from cells: Ambient: Unacceptable; Refrigerated: 1 week; Frozen: 1 month (avoid repeated freeze/thaw cycles)

Reference Interval

Test Number
Components
Reference Interval
  CK-MM 96-100%
  CK-MB 0-4%
  CK-BB 0%
  CK-Macro Type I 0%
  CK-Macro Type II 0%
  CK Total Effective February 22, 2022
Age:
Male:
Female:
0-30 days
31 days-5 months
6-35 months
3-6 years
7-17 years
18 years and older:
108-564 U/L
72-367 U/L
50-272 U/L
56-281 U/L
60-393 U/L
39-308 U/L
108-564 U/L
72-367 U/L
38-261 U/L
40-222 U/L
46-250 U/L
26-192 U/L

Interpretive Data



Compliance Category

FDA

Note

This test will detect CK macroenzymes.

Hotline History

N/A

CPT Codes

82552; 82550

Components

Component Test Code* Component Chart Name LOINC
0020020 CK-MM 15049-0
0020021 CK-MB 12187-1
0020022 CK-BB 15048-2
0020108 CK Total 2157-6
2001881 CK-Macro Type I 26019-0
2001882 CK-Macro Type II 26020-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • CK
  • CK Fractionation
  • CK Isoenzyme Electrophoresis
  • CK Isoenzymes
  • CK Macro
  • CK-BB
  • CK-MM
  • CKBB
  • CKMB
  • CPK
  • CPK Isoenzyme Electrophoresis
  • CPK Isoenzymes (Creatine Phosphokinase Isoenzymes)
  • Creatine Phosphokinase
  • Isoenzyme of Creatine Kinase
  • Isoenzymes, CK
  • Macro CK
  • Macro Creatine Kinase
  • Mitochondrial C
Creatine Kinase Isoenzymes