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  Lactate Dehydrogenase, Isoenzymes

LDISO
Example Reports
Abnormal
Normal

Ordering Recommendation

Do not use to detect myocardial injury. In rare cases, this test may be used to evaluate elevated lactate dehydrogenase associated with noncardiac muscle injury. Troponin testing is recommended for diagnosis and management of acute coronary syndrome; refer to Troponin T (cTnT) 5th Generation (3001831).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube (SST) or plain red.

Specimen Preparation

Do not refrigerate or freeze. Allow specimen to clot completely at room temperature. Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP standard transport tube. (Min: 0.6 mL)

Storage/Transport Temperature

Room temperature.

Unacceptable Conditions

Hemolyzed specimens.

Remarks
Stability

After separation of cells: Ambient: 1 week; Refrigerated: Unacceptable; Frozen: Unacceptable

Methodology

Quantitative Enzymatic Assay / Electrophoresis

Performed

Sun-Sat

Reported

1-3 days

Reference Interval

Test Number
 Components
 Reference Interval
  Lactate Dehydrogenase - 1 14-27%
  Lactate Dehydrogenase - 2 29-42%
  Lactate Dehydrogenase - 3 18-30%
  Lactate Dehydrogenase - 4 8-15%
  Lactate Dehydrogenase - 5 6-23%
  Lactate Dehydrogenase, Total
Age Reference Intervals (U/L)
0-1 month 200-465 U/L
2-17 months 200-450 U/L
18 months-10 years 165-430 U/L
11-16 years 127-287 U/L
17 years and older 105-230 U/L

Interpretive Data



Compliance Category

FDA

Note

  LD-1 and LD-2 are elevated in hemolyzed specimens and serum which has not been separated from cells. LD-3, LD-4, and LD-5 are labile at low temperatures, and are erroneously low in specimens that have been refrigerated or frozen.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
01/21/2025
X
N/A

CPT Codes

83625; 83615

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Components

Component Test Code* Component Chart Name LOINC
0020015 Lactate Dehydrogenase - 1 2536-1
0020016 Lactate Dehydrogenase - 2 2539-5
0020017 Lactate Dehydrogenase - 3 2542-9
0020018 Lactate Dehydrogenase - 4 2545-2
0020019 Lactate Dehydrogenase - 5 2548-6
0020107 Lactate Dehydrogenase, Total 14804-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Isoenzymes
  • Isoenzymes, LD
  • Isoenzymes of Lactate Dehydrogenase
  • Lactate Dehydrogenase Isoenzymes, Serum
  • LD
  • LDH
  • LDH Fractionation
  • LDH Isoenzymes
Lactate Dehydrogenase, Isoenzymes