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Lactate Dehydrogenase, Isoenzymes
Ordering Recommendation
Do not use to detect myocardial injury. In rare cases, this test may be used to evaluate elevated lactate dehydrogenase associated with noncardiac muscle injury. Troponin testing is recommended for diagnosis and management of acute coronary syndrome; refer to Troponin T (cTnT) 5th Generation (3001831).
New York DOH Approval Status
Specimen Required
Serum Separator Tube (SST) or Plain Red.
Do not refrigerate or freeze. Allow specimen to clot completely at room temperature. Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.6 mL)
Room temperature.
Hemolyzed specimens.
After separation of cells: Ambient: 1 week; Refrigerated: Unacceptable; Frozen: Unacceptable
Methodology
Quantitative Enzymatic Assay/Electrophoresis
Performed
Sun-Sat
Reported
1-2 days
Reference Interval
LD-1: 14-27%
LD-2: 29-42%
LD-3: 18-30%
LD-4: 8-15%
LD-5: 6-23%
Lactate Dehydrogenase, Total:
0-1 month: 200-465 U/L
2-17 months: 200-450 U/L
18 months-10 years: 165-430 U/L
11-16 years: 127-287 U/L
17 years and older: 105-230 U/L
Interpretive Data
FDA
Note
LD-1 and LD-2 are elevated in hemolyzed specimens and serum which has not been separated from cells. LD-3, LD-4, and LD-5 are labile at low temperatures, and are erroneously low in specimens that have been refrigerated or frozen.
Hotline History
CPT Codes
83625; 83615
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0020015 | Lactate Dehydrogenase - 1 | 2536-1 |
| 0020016 | Lactate Dehydrogenase - 2 | 2539-5 |
| 0020017 | Lactate Dehydrogenase - 3 | 2542-9 |
| 0020018 | Lactate Dehydrogenase - 4 | 2545-2 |
| 0020019 | Lactate Dehydrogenase - 5 | 2548-6 |
| 0020107 | Lactate Dehydrogenase, Total | 14804-9 |
Aliases
- Isoenzymes
- Isoenzymes of Lactate Dehydrogenase
- Isoenzymes, LD
- Lactate Dehydrogenase Isoenzymes, S
- LD
- LDH
- LDH Fractionation
- LDH Isoenzymes
