Ordering Recommendation

Use to assess cardiovascular disease risk and guide therapy.

Mnemonic
LDL D
Methodology

Quantitative Detergent Solubilization/ Enzymatic

Performed

Sun-Sat

Reported

Within 24 hours

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Plasma separator tube or serum separator tube. Also acceptable: Green (sodium or lithium heparin), lavender (EDTA), or pink (K2EDTA).

Specimen Preparation

Allow specimen to clot completely at room temperature. Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions
Remarks
Stability

After separation from cells: Ambient: 8 hours; Refrigerated: 5 days; Frozen: 1 month

Reference Interval
Age
Desirable
Borderline
Higher Risk
0-19 years 109 mg/dL or less 110-129 mg/dL 130 mg/dL or greater
20 years and older 129 mg/dL or less (99 mg/dL or less if patient has CHD) 130-159 mg/dL 160 mg/dL or greater

Interpretive Data

CHD Risk Factors:                                                            
+1  Age: Men, 45 years and older                                         
                Women, 55 years and older or premature menopause without estrogen therapy                                   
+1  Family history of premature CHD                                        
+1  Current smoking                                                        
+1  Hypertension                                                           
+1  Diabetes mellitus                                                      
+1  Low HDL Cholesterol: 39 mg/dL or less                                 
 -1  High HDL Cholesterol: 60 mg/dL or greater     
                                                                              
LDL Cholesterol: Therapeutic goal                                            
99 mg/dL or less if CHD is present  (Optional 69 mg/dL or less).   
129 mg/dL or less if no CHD and two or more risk factors.                  
159 mg/dL or less if no CHD. 
(Circulation 2004; 110:227-39)

Compliance Category

FDA

Note
Hotline History
N/A
CPT Codes

83721

Components
Component Test Code* Component Chart Name LOINC
0020257 LDL Cholesterol, Direct 18262-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Direct LDL
  • LDL
  • Low Density Lipoprotein
LDL Cholesterol, Direct