Ordering Recommendation

Useful in the assessment of deficiency or overload. Copper, Free, Serum or Plasma (3001971) may be a more specific indicator of copper overload. 


Quantitative Inductively Coupled Plasma-Mass Spectrometry




1-3 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter medications (upon the advice of their physician).


Royal Blue (No Additive), Royal Blue (K2EDTA), or Royal Blue (Na2EDTA).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL serum or plasma to an ARUP Trace Element-Free Transport Tube (ARUP supply #43116) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 0.5 mL)

Storage/Transport Temperature

Room temperature. Also acceptable: Refrigerated or frozen.

Unacceptable Conditions

Specimens that are not separated from the red cells or clot within 2 hours. Specimens collected in containers other than specified. Specimens transported in containers other than specified.


Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Indefinitely

Reference Interval
0-10 years 75.0-153.0 µg/dL 75.0-153.0 µg/dL
11 years-12 years 64.0-132.0 µg/dL 64.0-132.0 µg/dL
13 years-18 years 57.0-129.0 µg/dL 57.0-129.0 µg/dL
19 years and older 70.0-140.0 µg/dL 80.0-155.0 µg/dL

Interpretive Data

Elevated results may be due to skin or collection-related contamination, including the use of a noncertified metal-free collection/transport tube. If contamination concerns exist due to elevated levels of serum/plasma copper, confirmation with a second specimen collected in a certified metal-free tube is recommended.

Serum copper may be elevated with infection, inflammation, stress, and copper supplementation. In females, elevated copper may also be caused by oral contraceptives and pregnancy (concentrations may be elevated up to 3 times normal during the third trimester).

Serum copper may be reduced by use of corticosteroids and zinc and by malnutrition or malabsorption.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Hotline History
CPT Codes


Component Test Code* Component Chart Name LOINC
0020096 Copper, Serum/Plasma 5631-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Copper Plasma
  • Cu
  • Cu, Plasma
  • CUS
  • Kaiser Fleischer Ring
  • total blood copper level
Copper, Serum or Plasma