Copper, Serum or Plasma

0020096
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Specimen Collection and Handling
Ordering Recommendation

Useful in the assessment of deficiency or overload. Measures both protein-bound and free forms of copper in serum or plasma.

Mnemonic
COPPER
Methodology

Quantitative Inductively Coupled Plasma-Mass Spectrometry

Performed

Sun-Sat

Reported

1-3 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter medications (upon the advice of their physician).

Collect

Royal Blue (No Additive), Royal Blue (K2EDTA), or Royal Blue (Na2EDTA).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL serum or plasma to an ARUP Trace Element-Free Transport Tube (ARUP supply #43116) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 0.5 mL)

Storage/Transport Temperature

Room temperature. Also acceptable: Refrigerated or frozen.

Unacceptable Conditions

Specimens that are not separated from the red cells or clot within 2 hours. Specimens collected in containers other than specified. Specimens transported in containers other than specified.

Remarks
Stability

Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Indefinitely

Reference Interval
Age
 Male
 Female
0-10 years 75.0-153.0 µg/dL 75.0-153.0 µg/dL
11 years-12 years 64.0-132.0 µg/dL 64.0-132.0 µg/dL
13 years-18 years 57.0-129.0 µg/dL 57.0-129.0 µg/dL
19 years and older 70.0-140.0 µg/dL 80.0-155.0 µg/dL

Interpretive Data

Elevated results may be due to skin or collection-related contamination, including the use of a noncertified metal-free collection/transport tube. If contamination concerns exist due to elevated levels of serum/plasma copper, confirmation with a second specimen collected in a certified metal-free tube is recommended.

Serum copper may be elevated with infection, inflammation, stress, and copper supplementation. In females, elevated copper may also be caused by oral contraceptives and pregnancy (concentrations may be elevated up to 3 times normal during the third trimester).

Serum copper may be reduced by use of corticosteroids and zinc and by malnutrition or malabsorption.

Compliance Category

Laboratory Developed Test (LDT)

Note
Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
02/18/2020
X
05/20/2019
X
X
X
X
X
X
N/A
CPT Codes

82525

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Components
Component Test Code* Component Chart Name LOINC
0020096 Copper, Serum/Plasma 5631-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Copper Plasma
  • Cu
  • Cu, Plasma
  • CUS
  • Kaiser Fleischer Ring
  • total blood copper level
Copper, Serum or Plasma