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HDL Cholesterol
Ordering Recommendation
Use to assess cardiovascular disease risk and guide therapy.
New York DOH Approval Status
Specimen Required
Plasma separator tube or serum separator tube.
Allow specimen to clot completely at room temperature. Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube.
Refrigerated.
After separation from cells: Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 month
Methodology
Detergent Solubilization/Enzymatic Assay
Performed
Sun-Sat
Reported
Within 24 hours
Reference Interval
Desirable: 40-59 mg/dL
Interpretive Data
An HDL cholesterol less than 40 mg/dL is low and constitutes a coronary heart disease risk factor. An HDL cholesterol greater than 60 mg/dL is a negative risk factor for coronary heart disease.
CHD Risk Factors
+1 Age: Men > 45
Women > 55 or premature menopause without estrogen therapy
+1 Family history of premature CHD
+1 Current smoking
+1 Hypertension
+1 Diabetes mellitus
+1 Low HDL cholesterol: < 40 mg/dL
-1 High HDL cholesterol: ≥ 60 mg/dL
FDA
Note
Assay interference (negative) may be observed when high concentrations of N-acetylcysteine (NAC) are present. Negative interference has also been reported with NAPQI (an acetaminophen metabolite), but only when concentrations are at or above those expected during acetaminophen overdose.
Hotline History
CPT Codes
83718
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0020053 | HDL Cholesterol | 2085-9 |
Aliases
- Cholesterol
- Cholesterol, HDL
- HDL
- HDL Direct
- High Density Lipoprotein
- High Density Lipoprotein, Cholesterol
