Direct Coombs (Anti-Human Globulin)

0013008
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Example Reports
IgG Negative C3 Positive
IgG Positive C3 Negative
IgG Positive C3 Positive
Negative
Positive

Ordering Recommendation

Use to detect in vivo coating of red blood cells (RBCs) with  immunoglobulin and complement degradation products on the patient's RBCs. Useful for antibody identification and evaluation of transfusion reactions, hemolytic disease of the fetus and newborn (HDFN), and autoimmune hemolytic anemia associated with disease and/or drugs.

Mnemonic

IRL-DC

Methodology

Hemagglutination

Performed

Mon-Fri

Reported

1-3 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Lavender (K2EDTA) or Pink (K2EDTA).

Specimen Preparation

Do not freeze.
Transport 5 mL whole blood. (Min: 1 ml)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Separator or gel tubes.

Remarks
Stability

Ambient: Unacceptable; Refrigerated: 1 week; Frozen: Unacceptable

Reference Interval

Negative

Interpretive Data



Compliance Category

FDA

Note

Hotline History

N/A

CPT Codes

86880

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Components

Component Test Code* Component Chart Name LOINC
0013008 Direct Coombs 13946-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • DAT
  • Direct Antiglobulin Test
  • Direct Antihuman Globulin Test
Direct Coombs (Anti-Human Globulin)