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Early-Onset Alzheimer's Panel, Sequencing
Ordering Recommendation
Diagnostic and presymptomatic testing for individuals with a clinical suspicion for or a family history of Alzheimer’s disease diagnosed before age 65. A patient history form is required before testing will be performed. Informed consent is required for testing in presymptomatic adults. Testing minors for adult-onset conditions is not recommended; testing will not be performed in minors without prior approval. For additional information, please contact an ARUP genetic counselor at 800-242-2787 ext. 2141.
New York DOH Approval Status
Specimen Required
Lavender or pink (EDTA) or yellow (ACD solution A or B).
New York State Clients: Two Lavender (EDTA)
Transport 3 mL whole blood. (Min: 2 mL)
New York State Clients: transport 8 mL (Min: 6mL) in two lavender (EDTA) tubes
Refrigerated.
Serum or plasma; grossly hemolyzed or frozen specimens; saliva, buccal brush, or swab; FFPE tissue.
Ambient: 72 hours; Refrigerated: 2 weeks; Frozen: Unacceptable
New York State Clients: Ambient: 10 days; Refrigerated: 10 days; Frozen: Unacceptable
Methodology
Massively Parallel Sequencing
Performed
Varies
Reported
10-15 days
Reference Interval
By report
Interpretive Data
Refer to report.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA-certified laboratory and is intended for clinical purposes.
Counseling and informed consent are recommended for genetic testing. Consent forms are available online.
Laboratory Developed Test (LDT)
Note
Genes tested: APP, PSEN1, PSEN2
Hotline History
Hotline History
CPT Codes
81405; 81406
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 3001586 | Alzheimer's Interp | 35474-6 |
| 3001672 | Alzheimer's Specimen | 31208-2 |
Aliases
- AD
- dementia
- familial Alzheimer's disease (FAD)
- presenile dementia
