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Muscle-Specific Kinase (MuSK) Antibody, IgG
3001576
Ordering Recommendation

Secondary diagnostic testing for patients with generalized or ocular myasthenia gravis and no detectable antibodies to acetylcholine receptor (AChR).

Mnemonic
MSK AB
Methodology
Quantitative Radioimmunoassay
Performed
Mon, Thu
Reported
2-8 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
One 4 mL Plain Red or Serum Separator Tube (SST). 
Specimen Preparation
Separate from cells ASAP or within 2 hours of collection.  Transfer 2 mL of serum to an ARUP Standard Transport Tube. (Min: 0.5 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Grossly lipemic, icteric, or hemolyzed specimens. 
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month (avoid multiple freeze/thaw cycles) 
Reference Interval
Negative0.00-0.03 nmol/L
Positive0.04 nmol/L or greater

Interpretive Data
Muscle-specific kinase (MuSK) antibody is found in a subset of patients with myasthenia gravis, primarily those seronegative for muscle acetylcholine receptor (AChR) antibody. Decreasing antibody levels may be associated with therapeutic response; therefore, clinical correlation must be strongly considered. A negative test result does not rule out a diagnosis of myasthenia gravis.

Compliance Statement A: For laboratory developed tests using a manufacturer labeled ASR as the reagent providing the specificity of the assay. Analyte Specific Reagent. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.

Note
Hotline History
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Components
Component Test Code*Component Chart NameLOINC
3001577Muscle-Specific Kinase (MuSK) Ab, IgG51716-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Muscle-Specific Kinase Antibody by RIA
  • Muscle-Specific Receptor Tyrosine Kinase
  • MuSK
  • MuSK Autoantibody