FOXO1 (FKHR) (13q14) Gene Rearrangement by FISH
3001297
Ordering Recommendation
Use in conjunction with histologic and clinical information for the diagnosis of alveolar rhabdomyosarcoma.
Mnemonic
FKHR_FISH
Methodology
Fluorescence in situ Hybridization
Performed
Monday-Friday
Reported
3-7 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
- Patient Preparation
- Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Protect paraffin block from excessive heat. Transport tissue block or 5 unstained (4-micron thick sections) positively charged slides in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787 (kit recommended, but not necessary). (Min. 2 slides)
- Collect
- Tumor tissue.
- Specimen Preparation
- Storage/Transport Temperature
- Room temperature or refrigerated. Ship in cooled container during summer months.
- Unacceptable Conditions
- Specimens fixed or processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives (B-4 or B-5). No tumor in tissue. Decalcified specimens.
- Remarks
- Include surgical pathology report.
- Stability
- Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
Reference Interval
By report
Interpretive Data
Refer to report.
Compliance Statement A: For laboratory developed tests using a manufacturer labeled ASR as the reagent providing the specificity of the assay. Analyte Specific Reagent. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.
Note
Hotline History
View Hotline History
CPT Code(s)
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
3000604 | FOXO1 FISH Reference Number | |
3000605 | FOXO1 FISH Source | |
3000606 | FOXO1 FISH Result | |
3000702 | Total Cell Count | |
3000703 | Scoring Method |
Aliases
- 13q14
- 13q14 (FOX01 or FKHR) Rearrangement FISH
- Alveolar Rhabdomyosarcoma
- FKHR FISH
- FKHR gene break-apart FISH
- FOX01 FISH
- FOX01 gene break-apart FIS
- FOXO1 (13q14) rearrangements FISH
- PAX7/FOXO1A