Feedback
Coccidioides Antibodies Panel, CSF by CF, ID, ELISA
3000061
Ordering Recommendation

Aid in diagnosis of coccidioidal meningitis (Valley fever).

Mnemonic
COCCIABCSF
Methodology
Semi-Quantitative Complement Fixation/Qualitative Immunodiffusion/Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Sun-Sat
Reported
2-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
CSF. 
Specimen Preparation
Transfer 2.5 mL CSF to an ARUP Standard Transport Tube. (Min: 1 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Other body fluids. Contaminated, hemolyzed, xanthochromic, or severely lipemic specimens. 
Remarks
Mark specimens plainly as "acute" or "convalescent." 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles) 
Reference Interval
Test Number
Components
Reference Interval
3000058Coccidioides immitis by Immunodiffusion, CSFNone detected.
3000059Coccidioides Antibody by CF, CSFLess than 1:2
3000055Coccidioides Antibody IgG ELISA, CSF
0.9 IV or lessNegative - No significant level of Coccidioides IgG antibody detected.
1.0-1.4 IVEquivocal - Questionable presence of Coccidioides IgG antibody detected. Repeat testing in 10-14 days may be helpful.
1.5 IV or greaterPositive - Presence of IgG antibody to Coccidioides detected, suggestive of current or past infection.

3000056Coccidioides Antibody IgM ELISA, CSF
0.9 IV or lessNegative - No significant level of Coccidioides IgM antibody detected.
1.0-1.4 IVEquivocal - Questionable presence of Coccidioides IgM antibody detected. Repeat testing in 10-14 days may be helpful.
1.5 IV or greaterPositive - Presence of IgM antibody to Coccidioides detected, suggestive of current or recent infection.


Interpretive Data
Refer to report.

Compliance Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
For Coccidioides, immunodiffusion (ID) measures IgM antibody, while complement fixation (CF) measures both IgG and IgM. ELISA tests can be used to detect both coccidioidal IgG and IgM antibodies. While elevated single antibody titers may be diagnostic, paired specimens are preferred. Acute and convalescent specimens (drawn at least 21 days apart), showing a fourfold or greater rise in titer, are diagnostic.

Negative fungal serology does not rule out the possibility of current infection.
Components
Component Test Code*Component Chart NameLOINC
0050711Coccidioides Ab by CF, CSF13917-0
3000062Coccidioides Antibody IgG ELISA, CSF16638-9
3000063Coccidioides Antibody IgM ELISA, CSF16639-7
3000064Coccidioides by Immunodiffusion, CSF21209-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases