Coccidioides immitis by Immunodiffusion, CSF
Ordering Recommendation

Not recommended. For diagnosis of coccidioidal meningitis (Valley fever), refer to Coccidioides Antibodies Panel, CSF by CF, ID, ELISA (3000061) which combines complement fixation, immunodiffusion, and enzyme-linked immunosorbent assays.

Qualitative Immunodiffusion
2-4 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Specimen Preparation
Transfer 1 mL CSF to an ARUP Standard Transport Tube. (Min: 0.6 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Contaminated, hemolyzed, xanthochromic, or severely lipemic specimens. 
Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles) 
Reference Interval
None detected.
Interpretive Data
Coccidioides infection is demonstrated by the detection of IgM antibody to the Immunodiffusion Tube Precipitin (IDTP) antigen. IgM antibody may be detected 1 to 3 weeks after the onset of primary infection and may suggest active or recent infection. IgM antibody is rarely detected 6 months after infection but may reappear with relapse and may persist in disseminated cases.

IgG antibody may also be demonstrated in response to the Immunodiffusion Complement Fixation (IDCF) antigen and may represent active or past infection. Negative fungal serology does not rule out current infection.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

This test uses culture filtrates of Coccidioides immitis and includes IDCF and IDTP antigens.
Hotline History
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Component Test Code*Component Chart NameLOINC
3000064Coccidioides by Immunodiffusion, CSF21209-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Coccidioides Antibody (TP Antigen)
  • Coccidioides Antibody (TP Antigen), Immunodiffusion
  • Coccidioides antibody, S
  • Coccidioides Precipitin
  • Coccidioidomycosis IgG/IgM
  • San Joaquin Fever Antibody
  • San Joaquin Valley fever
  • Valley Fever antibodies, Cocci ID