Zika Virus IgM Antibody Capture (MAC), by ELISA
Ordering Recommendation

Use for patients whose symptoms began, or whose documented exposure occurred, at least 14 days prior to testing. Should also be used as follow-up for patients with negative serum and urine results from molecular testing performed less than 14 days after symptom onset.

Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Mon, Wed, Fri
1-6 days
New York DOH Approval Status
This test is New York DOH approved.
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Serum Separator Tube (SST). 
Specimen Preparation
Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 1.0 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. Mark specimen plainly as "acute or convalescent." 
Storage/Transport Temperature
Unacceptable Conditions
Contaminated, heat-inactivated, hemolyzed, or severely lipemic specimens. 
Submit patient history. 
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles) 
Reference Interval
Interpretive Data
The possibility of false-positive or false-negative results must be considered. RT-PCR testing on both a serum and urine specimen is recommended by the Centers for Disease Control and Prevention (CDC) to rule out false-negative IgM results in patients experiencing symptoms for less than 2 weeks. Specimens collected for IgM testing greater than or equal to 2 weeks after symptom onset do not require any additional testing. For more information, please review the current clinical guidelines for Zika virus testing at:

If the result is "Presumptive Zika," then Zika IgM Ab Capture (MAC) Confirmation (ARUP test code 3001904) will be added at no additional charge.
Hotline History
View Hotline History
Component Test Code*Component Chart NameLOINC
2014017Zika Virus IgM Ab Capture (MAC), ELISA80824-6
2014019Relevant Zika virus Exposure?
2014020Symptoms consistent with Zika virus?75325-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.