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Hemoglobin S, Sickle Solubility
2013399
Ordering Recommendation

Effective test for secondary confirmation of hemoglobin (Hb) S. Not recommended for newborns <6 months due to high concentration of HbF. Confirm results with Hemoglobin Evaluation with Reflex to Electrophoresis and/or RBC Solubility (0050610). 

Mnemonic
SICKLE
Methodology
RBC Solubility
Performed
Sun-Sat
Reported
1-3 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Lavender (EDTA) or pink (K2EDTA). 
Specimen Preparation
Transport 5 mL whole blood. (Min: 0.2 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
 
Remarks
 
Stability
Ambient: Unacceptable; Refrigerated: 1 week; Frozen: Unacceptable 
Reference Interval
Interpretive Data
Refer to report.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
Hotline History
N/A
Components
Component Test Code*Component Chart NameLOINC
2013400Sickle Cell Solubility Result6864-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Hb S
  • Hgb S
  • Sickle Cell Anemia Screen
  • Sickle Cell Disease