Primarily aids the distinction between CLL/SLL and mantle cell lymphoma where CD200 is usually positive in CLL/SLL and negative in mantle cell lymphoma. CD200 is also positive in other B-cell lymphoproliferative disorders.
- Patient Preparation
- Specimen Preparation
- Formalin fix (10 percent neutral buffered formalin) and paraffin embed specimen (cells must be prepared into a cellblock). Protect paraffin block and/or slides from excessive heat. Transport tissue block or 5 unstained (3- to 5-micron thick sections), positively charged slides in a tissue transport kit (recommended but not required), (ARUP supply #47808) available online through eSupply using ARUP Connect or contact ARUP Client Services at (800) 522-2787. (Min: 2 slides) If sending precut slides, do not oven bake.
- Storage/Transport Temperature
- Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months.
- Unacceptable Conditions
- Specimens submitted with non-representative tissue type. Depleted specimens.
- Ambient: Indefinitely, Refrigerated: Indefinitely, Frozen: Unacceptable
|Component Test Code*||Component Chart Name||LOINC|
|2012845||CD200 Client Case or Reference Number|
|2012846||CD200 by Immunohistochemistry|