SSA 52 and 60 (Ro) (ENA) Antibodies, IgG

2012074

Ordering Recommendation

Order as secondary screen based on results of ANA test or if ANA IFA is negative and Sjögren syndrome, systemic lupus erythematosus (SLE), systemic sclerosis, or myositis is strongly suspected.

Mnemonic

SSA RO

Methodology

Semi-Quantitative Multiplex Bead Assay

Performed

Sun-Sat

Reported

1-2 days

New York DOH Approval Status

This test is New York DOH approved.

Submit With Order

Additional Technical Information

ARUP Consult®

Disease Topics

Interface Map

Specimen Required

Patient Preparation
Collect: Serum separator tube (SST).
Specimen Preparation: Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.2 mL)
Storage/Transport Temperature: Refrigerated.
Unacceptable Conditions: Plasma or other body fluids. Contaminated, hemolyzed, or severely lipemic specimens.
Remarks
Stability: After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval

Test Number	Components	Reference Interval
	SSA-52 (Ro52) (ENA) Antibody, IgG	29 AU/mL or Less: Negative 30-40 AU/mL: Equivocal 41 AU/mL or greater: Positive
	SSA-60 (Ro60) (ENA) Antibody, IgG	29 AU/mL or Less: Negative 30-40 AU/mL: Equivocal 41 AU/mL or greater: Positive

Interpretive Data

SSA-52 (Ro52) and/or SSA-60 (Ro60) antibodies are associated with a diagnosis of Sjögren syndrome, systemic lupus erythematosus (SLE), and systemic sclerosis. SSA-52 antibody overlaps significantly with the major SSc-related antibodies. SSA-52 (Ro52) antibody occurs frequently in patients with inflammatory myopathies, often in the presence of interstitial lung disease.

Note

Hotline History

N/A

CPT Code(s)

86235 x2

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Components

Component Test Code*	Component Chart Name	LOINC
0050691	SSA-52 (Ro52) (ENA) Antibody, IgG	31625-7
2012055	SSA-60 (Ro60) (ENA) Antibody, IgG	53019-6

* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

Anti-Ro
Anti-SSA; Anti-SSA (Ro) (ENA) Antibody
Ro
Ro Autoantibodies
Sjogren Syndrome
Sjogren's Antibody
SSA Autoantibodies

Date of Change	Test Name Change	Methodology	Performance/Reported Schedule	Specimen Requirements	Reference Interval	Interpretive Data	Note	CPT Code	Component Change	Other Interface Change	New Test	Inactive

COMPONENT	DESCRIPTION	TEST TYPE	INFECTIOUS	UNIT OF MEASURE	NUMERIC MAP	LOINC
0050691	SSA-52 (Ro52) (ENA) Antibody, IgG	Resultable	N	AU/mL	XXX	31625-7
2012055	SSA-60 (Ro60) (ENA) Antibody, IgG	Resultable	N	AU/mL	XXX	53019-6

For questions regarding the Interface Map, please contact interface.support@aruplab.com.

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