Ordering Recommendation

Aids in diagnosis of acute myelocytic leukemia or other leukemias, sarcoidosis, and infections such as tuberculosis.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube (SST).

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.4 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Hemolyzed, lipemic, icteric, or contaminated specimens.

Remarks
Stability

After separation from cells: Ambient: Unacceptable; Refrigerated: 5 days; Frozen: 1 month.

Methodology

Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)

Performed

Sun, Tue, Thu

Reported

1-5 days

Reference Interval

Test Number
Components
Reference Interval
  Lysozyme, Serum Less than or equal to 4.50 ug/mL

Interpretive Data

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.


Component
Interpretation
Lysozyme, Serum 2.75 ug/mL or less ......... Negative
2.76 - 4.50 ug/mL .......... Equivocal
4.51 ug/mL or greater ...... Positive

Compliance Category

Laboratory Developed Test (LDT)

Note

Serum lysozyme levels may be elevated in acute myelomonocytic leukemia (FAB-M4), chronic myelomonocytic leukemia (CMML), and chronic myelocytic leukemia (CML). Increased serum lysozyme activity is present in tuberculosis, sarcoidosis, megaloblastic anemias, acute bacterial infections, ulcerative colitis, regional enteritis, and Crohn disease. Elevated serum lysozyme occurs during severe renal insufficiency, renal transplant rejection, urinary tract infections, pyelonephritis, glomerulonephritis, and nephrosis.

Hotline History

N/A

CPT Codes

85549

Components

Component Test Code* Component Chart Name LOINC
2012040 Lysozyme, Serum 2589-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Muramidase serum
  • Serum lysozyme
Lysozyme, Serum