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Hereditary Breast and Ovarian Cancer Panel, Sequencing and Deletion/Duplication
2012026
Ordering Recommendation

Preferred first-tier genetic test to diagnose a hereditary cancer syndrome related to breast and ovarian cancer, if a known familial variant has NOT been previously identified. When a relative has a previously identified pathogenic variant, see Familial Mutation, Targeted Sequencing (2001961). For detailed ordering recommendations, see the Additional Technical Information (ATI) document.

Mnemonic
BOCAPAN
Methodology
Massively Parallel Sequencing/Exonic Oligonucleotide-based CGH Microarray
Performed
Varies
Reported
3-6 weeks
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Lavender (EDTA) or yellow (ACD Solution A or B). 
Specimen Preparation
Transport 3 mL whole blood. (Min: 1 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
 
Remarks
 
Stability
Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable 
Reference Interval
By report
Interpretive Data
Refer to report.

Compliance Statement C: For human genetic inheritable conditions and mutations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Counseling and informed consent are recommended for genetic testing. Consent forms are available online.

Note
Genes tested by Sequencing: ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2 common mutations, MEN1, MLH1, MSH2, MSH6, MUTYH, NBN, PALB2, PTEN, RAD51C, RAD51D, STK11, TP53

Genes tested by Deletion/Duplication: ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2 common mutations, EPCAM deletions only, MEN1,MLH1, MSH2, MSH6, MUTYH, NBN, PALB2, PTEN, RAD51C, RAD51D, STK11, TP53
Hotline History
View Hotline History
CPT Code(s)
81432; 81433
Components
Component Test Code*Component Chart NameLOINC
2012028Breast/Ovarian Cancer Panel Interp35474-6
2012029Breast/Ovarian Cancer Panel Spcm31208-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • ATM
  • BARD1
  • BRCA1
  • BRCA2
  • BRIP1
  • CDH1
  • CHEK2 common mutations
  • EPCAM deletions only
  • MEN1
  • MLH1
  • MSH2
  • MSH6
  • MUTYH
  • NBN
  • PALB2
  • PTEN
  • RAD51C
  • RAD51D
  • STK11
  • TP53