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Breast and Ovarian Hereditary Cancer Panel, Sequencing and Deletion/Duplication, 20 Genes
2012026
Ordering Recommendation

Preferred first-tier genetic test to diagnose a hereditary cancer syndrome related to breast and ovarian cancer, including hereditary breast and ovarian cancer syndrome (HBOC), if a known familial variant has NOT been previously identified. When a relative has been previously tested, see Familial Mutation, Targeted Sequencing (2001961).

Mnemonic
BOCAPAN
Methodology
Massively Parallel Sequencing/Exonic Oligonucleotide-based CGH Microarray
Performed
Varies
Reported
10-12 weeks
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
 
Collect
Lavender (EDTA) or yellow (ACD Solution A or B). 
Specimen Preparation
Transport 3 mL whole blood. (Min: 1 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
 
Remarks
 
Stability
Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable 
Reference Interval
By report
Interpretive Data
Refer to report.

Compliance Statement C: The performance characteristics of this test were validated by ARUP Laboratories. The U.S. Food and Drug Administration (FDA) has not approved or cleared this test. However, FDA approval or clearance is currently not required for clinical use of this test. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. ARUP is authorized under Clinical Laboratory Improvement Amendments (CLIA) and by all states to perform high-complexity testing. Counseling and informed consent are recommended for genetic testing. Consent forms are available online.

Note
Genes tested by Sequencing: ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2 common mutations, MEN1,MLH1, MSH2, MSH6, MUTYH, NBN, PALB2, PTEN, RAD51C, RAD51D, STK11, TP53

Genes tested by Deletion/Duplication: ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2 common mutations, EPCAM deletions only, MEN1,MLH1, MSH2, MSH6, MUTYH, NBN, PALB2, PTEN, RAD51C, RAD51D, STK11, TP53
Components
Component Test Code*Component Chart NameLOINC
2012028Breast/Ovarian Cancer Panel Interp35474-6
2012029Breast/Ovarian Cancer Panel Spcm31208-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • ATM
  • BARD1
  • BRCA1
  • BRCA2
  • BRIP1
  • CDH1
  • CHEK2 common mutations
  • EPCAM deletions only
  • MEN1
  • MLH1
  • MSH2
  • MSH6
  • MUTYH
  • NBN
  • PALB2
  • PTEN
  • RAD51C
  • RAD51D
  • STK11
  • TP53