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Human Papillomavirus (HPV), High Risk with 16 and 18 Genotype by PCR, ThinPrep
2011940
Ordering Recommendation

FDA-approved platform for primary HPV screening in women ≥25 years. FDA-approved test for routine cervical cancer screening in combination with cervical cytology (Pap smear) in women ≥30 years. Follow-up test for abnormal cytology results in women ≥21 years.

Mnemonic
TP HPV1618
Methodology
Qualitative Polymerase Chain Reaction
Performed
Mon, Wed, Fri
Reported
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Cervical specimen with brush or spatula from ThinPrep kit and place in PreservCyt Media. 
Specimen Preparation
Mix well. Transfer 3 mL to an ARUP Standard Transport Tube. (Min 1.5 mL). If test is being used for primary screening, submit specimen aliquot and retain the original specimen at the client site. 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Bloody or dark brown specimens. Specimens in any media other than indicated above. 
Remarks
Specimen source required. 
Stability
Ambient: 6 months; Refrigerated: 6 months; Frozen: Unacceptable 
Reference Interval
Negative
Interpretive Data
This test amplifies DNA of HPV16, HPV18 and 12 other high-risk HPV types (31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68) associated with cervical cancer and its precursor lesions. Sensitivity may be affected by specimen collection methods, stage of infection, and the presence of interfering substances. Results should be interpreted in conjunction with other available laboratory and clinical data. A negative high-risk HPV result does not exclude the presence of other high-risk HPV types, the possibility of future cytologic abnormalities, underlying CIN2-3, or cancer.

This test is intended for medical purposes only and is not valid for the evaluation of suspected sexual abuse or for other forensic purposes. HPV testing should not be used for screening or management of atypical squamous cells of undetermined significance (ASCUS) in women under age 21.

Note
CPT Code(s)
87624
Components
Component Test Code*Component Chart NameLOINC
0060752HPV Source31208-2
2011935HPV Genotype 16 by PCR61372-9
2011936HPV, Other High Risk by PCR70061-7
2011941HPV Genotype 18 by PCR61373-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • HPV High Risk
  • HPV HR ThinPrep
  • HPV Primary screening
  • Human papilloma virus