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Alpha-Iduronidase Enzyme Activity in Leukocytes
2011415
Ordering Recommendation

Use to diagnose patients for mucopolysaccharidosis type I (also known as MPS I, Hurler, Scheie, and Hurler-Scheie syndromes). To screen for all types of MPS, refer to Mucopolysaccharides Screen - Electrophoresis & Quantitation, Urine (0081352). To monitor glycosaminoglycans (GAGs) in patients previously diagnosed with MPS, refer to Mucopolysaccharides, Quantitative, Urine (0081357).

Mnemonic
A-I LEUK
Methodology
Quantitative Fluorometry
Performed
Varies
Reported
3-10 days
New York DOH Approval Status
This test is New York DOH approved.
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Yellow (ACD Solution B), Lavender (K2EDTA), or Lavender (K3EDTA). 
Specimen Preparation
Transport 3 mL whole blood. (Min: 1 mL) 
Storage/Transport Temperature
Room Temperature  (Preferred) or Refrigerated 
Unacceptable Conditions
Grossly hemolyzed or heparinized specimens. 
Remarks
Additional information is required: Clinical Indication for testing. 
Stability
Ambient: 3 days; Refrigerated: 3 days; Frozen: Unacceptable 
Reference Interval
12 - 65 nmol hydrolyzed/hr/mg protein
Interpretive Data
Refer to report.

Note
CPT Code(s)
82657
Components
Component Test Code*Component Chart NameLOINC
2011416Alpha-Iduronidase Activity, Leukocytes24057-2
2011417Alpha-Iduronidase, Leukocytes, Interp48767-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Hunter
  • Hunter-Scheie
  • Mucopolysaccharidosis Type I
  • Scheie