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Alpha-Iduronidase Enzyme Activity in Leukocytes
2011415
Ordering Recommendation

Use to diagnose patients for mucopolysaccharidosis type I (also known as MPS I, Hurler, Scheie, and Hurler-Scheie syndromes). To screen for all types of MPS, refer to Mucopolysaccharides Screen - Electrophoresis & Quantitation, Urine (0081352). To monitor glycosaminoglycans (GAGs) in patients previously diagnosed with MPS, refer to Mucopolysaccharides, Quantitative, Urine (0081357).

Mnemonic
A-I LEUK
Methodology
Quantitative Fluorometry
Performed
Varies
Reported
3-10 days
New York DOH Approval Status
This test is New York DOH approved.
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Yellow (ACD Solution B), Lavender (K2EDTA), or Lavender (K3EDTA). 
Specimen Preparation
Transport 3 mL whole blood. (Min: 1 mL) 
Storage/Transport Temperature
Room Temperature  (Preferred) or Refrigerated 
Unacceptable Conditions
Grossly hemolyzed or heparinized specimens. 
Remarks
Additional information is required: Clinical Indication for testing. 
Stability
Ambient: 3 days; Refrigerated: 3 days; Frozen: Unacceptable 
Reference Interval
12 - 65 nmol hydrolyzed/hr/mg protein
Interpretive Data
Refer to report.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
Hotline History
N/A
Components
Component Test Code*Component Chart NameLOINC
2011416Alpha-Iduronidase Activity, Leukocytes24057-2
2011417Alpha-Iduronidase, Leukocytes, Interp48767-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Hunter
  • Hunter-Scheie
  • Mucopolysaccharidosis Type I
  • Scheie