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Amyotrophic Lateral Sclerosis (ALS) Panel, Sequencing and Deletion/Duplication, 11 Genes
2011152
Ordering Recommendation

Confirm clinical diagnosis of amyotrophic lateral sclerosis (ALS).

Mnemonic
ALS PANEL
Methodology
Massively Parallel Sequencing/Exonic Oligonucleotide-based CGH Microarray
Performed
Varies
Reported
10-12 weeks after receipt of fully completed ALS required consent form
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Lavender (EDTA) or yellow (ACD Solution A or B). 
Specimen Preparation
Transport 3 mL whole blood. (Min: 1 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
 
Remarks
 
Stability
Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable 
Reference Interval
By report
Interpretive Data
Refer to report.

Informed consent is required for ALS genetic testing. Consent forms are available online at www.aruplab.com.

Compliance Statement C: The performance characteristics of this test were validated by ARUP Laboratories. The U.S. Food and Drug Administration (FDA) has not approved or cleared this test. However, FDA approval or clearance is currently not required for clinical use of this test. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. ARUP is authorized under Clinical Laboratory Improvement Amendments (CLIA) and by all states to perform high-complexity testing. Counseling and informed consent are recommended for genetic testing. Consent forms are available online.

Note
Genes tested, sequencing and deletion/duplication: ALS2, ANG, FIG4, FUS, OPTN, SETX, SOD1, TARDBP, UBQLN2, VAPB, VCP.
A completed ALS specific consent form, signed by the patient (or legal guardian) and physician, is required for all specimens. Testing for patients under the age of 18 years or fetal specimens is not offered. Presymptomatic counseling is recommended by a genetics professional prior to testing. Call Genetics Processing with additional questions at 800-242-2787 ext 3301.
CPT Code(s)
81403 (ANG), 81404 (SOD1), 81405 (TARDBP), 81406 x4 (FIG4, FUS, OPTN, SETX), 81479 x2
Components
Component Test Code*Component Chart NameLOINC
2011206ALS Panel Specimen31208-2
2011209ALS Panel Interpretation35474-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • ALS2, ANG, FIG4, FUS, OPTN, SETX, SOD1, TARDBP, UBQLN2, VAPB, VCP
  • Familial Amyotrophic Lateral Sclerosis (FALS)
  • Frontotemporal dementia (FTD)
  • Genes tested, sequencing and deletion/duplication: ALS2, ANG, FIG4, FUS, OPTN, SETX
  • Lou Gehrig's disease
  • SOD1, TARDBP, UBQLN2, VAPB, VCP