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Acute Myeloid Leukemia Panel by FISH
2011132
Ordering Recommendation

Identify prognostically important abnormalities in newly diagnosed AML. Monitor response to therapy with specific probes (CHR FISHI) or progression of disease with probe panel.

Mnemonic
FISH AML
Methodology
Fluorescence in situ Hybridization
Performed
Sun-Sat
Reported
3-10 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Non-diluted bone marrow aspirate collected in a heparinized syringe. Also acceptable: Whole blood in green (sodium heparin).
Other specimen types may be acceptable, contact the Cytogenetics Laboratory for specific specimen collection and transportation instructions. 
Specimen Preparation
Transfer bone marrow to a green (sodium heparin). Transport 3 mL bone marrow. (Min: 1 mL) OR Transport 5 mL whole blood. (Min: 2 mL) 
Storage/Transport Temperature
Room temperature 
Unacceptable Conditions
Clotted or paraffin-embedded specimens. 
Remarks
 
Stability
Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable 
Reference Interval
Normal
Interpretive Data
Probes included: RPN1/MECOM (EVI1), EGR1, D7S486, RUNX1T1/RUNX1, KMT2A (MLL), and CBFB. The probe for PML/RARα is added automatically and is performed along with the panel. However, due to the longer turnaround time required for the panel, the result of this probe is reported as soon as available and is charged separately. (See PML-RARA Translocation by FISH, ARUP test code 2002363)

Compliance Statement A: Analyte specific reagents (ASR) are used in many laboratory tests necessary for standard medical care and generally do not require U.S. Food and Drug Administration (FDA) approval or clearance. This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. This test should not be regarded as investigational or for research use.

Note
If cell pellets or dropped cytogenetic slides are submitted, processing fee will not apply.
Other specimen types may be acceptable, contact the Cytogenetics Laboratory for specific specimen collection and transportation instructions.

A processing fee will be charged if this procedure is canceled, at the client's request, after the test has been set up, or if the specimen integrity is inadequate to allow culture growth. The fee will vary based on specimen type.
CPT Code(s)
88271 x6; 88275 x6; 88291
Components
Component Test Code*Component Chart NameLOINC
2002385FISH AML Panel
2011228EER AML Panel by FISH
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • 'Fluorescence in situ hybridization
  • AML Panel
  • FISH
  • myelogenous leukemia
  • oncology FISH probes