•Identify eosinophil involvement by staining for eosinophil granule major basic protein 1 (eMBP1) and eosinophil-derived neurotoxin (EDN) to detect both cellular localization and extracellular deposition.
•Eosinophil granule proteins are toxic to tissues and cells and may be pathogenic in disease but not recognized when deposited outside of morphologically identifiable intact eosinophils.
- Patient Preparation
- Specimen Preparation
- Transport tissue in Michel's media (ARUP supply #45462) available online through eSupply using ARUP Connect or call ARUP Client Services at (800) 522-2787. Also acceptable: Zeus tissue fixative.
- Storage/Transport Temperature
- Room temperature.
- Unacceptable Conditions
- Ambient: 10 days; Refrigerated: 10 days; Frozen: Unacceptable
|Component Test Code*||Component Chart Name||LOINC|
|2010911||EER Eosinophil Granule MBP in Tissues|
|2010922||Eosinophil Granule MBP in Tissues|
Performed at UUHC-Immunodermatology