• Identify eosinophil involvement by staining for eosinophil granule major basic protein 1 (eMBP1) and eosinophil-derived neurotoxin (EDN) to detect both cellular localization and extracellular deposition.
• Eosinophil granule proteins are toxic to tissues and cells and may be pathogenic in disease but not recognized when deposited outside of morphologically identifiable intact eosinophils.
- Patient Preparation
- Specimen Preparation
- Transport tissue in Michel's media (ARUP supply #45462) available online through eSupply using ARUP Connect or call ARUP Client Services at (800) 522-2787. Also acceptable: Zeus tissue fixative.
- Storage/Transport Temperature
- Room temperature.
- Unacceptable Conditions
- Ambient: 10 days; Refrigerated: 10 days; Frozen: Unacceptable
|Component Test Code*||Component Chart Name||LOINC|
|2010911||EER Eosinophil Granule MBP in Tissues|
|2010922||Eosinophil Granule MBP in Tissues|
Performed at UUHC-Immunodermatology