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Paraneoplastic Antibodies (PCCA/ANNA) by IFA with Reflex to Titer and Immunoblot, CSF
2010841
Ordering Recommendation

Aid in the diagnosis of paraneoplastic neurologic syndromes associated with malignancy for CSF specimens only. Order based on clinical presentation. PCCA/ANNA antibodies are screened by IFA; if IFA screen is positive, a specific titer (PCCA or ANNA) and immunoblot will be added.

Mnemonic
PCCAANNA C
Methodology
Semi-Quantitative Indirect Fluorescent Antibody/Qualitative Immunoblot
Performed
Wed
Reported
1-9 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
CSF  
Specimen Preparation
Transfer 2 mL CSF to an ARUP Standard Transport Tube. (Min: 0.75 mL)  
Storage/Transport Temperature
Refrigerated  
Unacceptable Conditions
Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.  
Remarks
 
Stability
Ambient: 24 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
Test Number
Components
Reference Interval
 Paraneoplastic Abs (PCCA/ANNA) IgG, CSFNone Detected
 Neuronal Nuclear Ab Titer, IgG CSFLess than 1:1
 Purkinje Cell Antibody Titer IgG, CSFLess than 1:1
 Neuronal Nuclear Abs IgG ImmunoBlot, CSFNone Detected

Interpretive Data


Compliance Statement D: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
Note
PCCA/ANNA antibodies are screened by IFA. If the IFA screen is positive at 1:1, then a specific titer (PCCA or ANNA) and Immunoblot will be added. Additional charges apply.
CPT Code(s)
86255; if reflexed add 86256 and 83516
Components
Component Test Code*Component Chart NameLOINC
2010842Paraneoplastic Abs (PCCA/ANNA) IgG, CSF
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases