Noonan Spectrum Disorders Panel, Sequencing, 15 Genes
2010772
Ordering Recommendation
Preferred test for individuals with clinical phenotype of Noonan syndrome, cardiofaciocutaneous syndrome, Costello syndrome, LEOPARD syndrome, Legius syndrome, or Noonan-like syndrome.
Mnemonic
NOONAN SEQ
Methodology
Massive Parallel Sequencing
Performed
Varies
Reported
10-12 weeks  
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
  
Collect
Lavender (EDTA) or yellow (ACD Solution A or B).  
Specimen Preparation
Transport 3 mL whole blood. (Min: 1 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
  
Remarks
  
Stability
Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable  
Reference Interval
By report  
Interpretive Data
Refer to report.



Counseling and informed consent are recommended for genetic testing. Consent forms are available online at www.aruplab.com.

See Compliance Statement C: www.aruplab.com/CS  
Note
 
CPT Code(s)
81404 (HRAS); 81405x3 (KRAS, SHOC2, SPRED1); 81406 x6 (BRAF, MAP2K1, MAP2K2, PTPN11, RAF1, SOS1); 81479
Components
Component Test Code*Component Chart Name
2010773Noonan Disorders Sequencing Specimen
2010774Noonan Disorders Sequencing Interp
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • BRAF, CBL, HRAS, KAT6B, KRAS, MAP2K1, MEK1, MAP2K2, MEK2, NRAS, PTPN11
  • Cardiofaciocutaneous syndrome, Costello syndrome, Multiple lentigines syndrome, LEOPARD syndrome
  • RAB40AL, RAF1, RIT1, SHOC2, SOS1, SPRED1