Mycophenolic Acid and Metabolites
Ordering Recommendation
Therapeutic monitoring for individuals taking mycophenolate. Predose (trough) concentration at steady state should be assessed.
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
1-2 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.  
Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).  
Specimen Preparation
Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.1 mL)  
Storage/Transport Temperature
Unacceptable Conditions
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).  
After separation from cells: Ambient: 6 weeks; Refrigerated: 6 weeks; Frozen: 11 months  
Reference Interval
Available Separately Component Therapeutic Range Toxic
No Mycophenolic Acid 1.0 -​ 3.5 µg/mL Greater than 25.0 µg/mL
No Mycophenolic Acid Glucuronide 35.0-​100.0 µg/mL Not well established
No Mycophenolic Acid acyl-​glucuronide Not well established Not well established
Interpretive Data
The therapeutic range is based on serum pre-dose (trough) draw at steady-state concentration. A proposed therapeutic range is 1.0-3.5 µg/mL for a 2 g/day dose. A 3 g/day dose may have plasma concentrations up to 5.0 µg/mL. Trough concentrations between 2.0 and 4.0 µg/mL have been suggested to maximize efficacy and minimize adverse effects. Mycophenolic acid glucuronide is an inactive metabolite and a range of 35.0-100.0 µg/mL indicates normal metabolism. During the first two weeks of transplantation, mycophenolic acid glucuronide concentrations are typically 100-250 µg/mL. Mycophenolic acid acyl-glucuronide is an active metabolite and the therapeutic and toxic ranges are not well established. Adverse effects of toxicity include abdominal pain, peripheral edema, cardiac abnormalities, hypertension and electrolyte disturbances.  
CPT Code(s)
Component Test Code*Component Chart NameLOINC
0090213Mycophenolic Acid55806-4
2010110Mycophenolic Acid Glucuronide55807-2
2010111Mycophenolic Acid Acyl-Glucuronide 
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Cellcept™
  • CellCept™ MPA
  • Myfortic™;