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Renal Hereditary Cancer Panel, Sequencing and Deletion/Duplication, 15 Genes 
2010214
Ordering Recommendation

Preferred test to confirm a diagnosis of hereditary renal cancer syndrome in individuals with personal or family history of renal cancer.

Mnemonic
RENCAPAN
Methodology
Massively Parallel Sequencing/Exonic Oligonucleotide-based CGH Microarray
Performed
Varies
Reported
10-12 weeks
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Lavender (EDTA) or yellow (ACD Solution A or B). 
Specimen Preparation
Transport 3 mL whole blood. (Min: 1 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
 
Remarks
 
Stability
Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable 
Reference Interval
By report
Interpretive Data
Refer to report.

Compliance Statement C: For human genetic inheritable conditions and mutations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Counseling and informed consent are recommended for genetic testing. Consent forms are available online.

Components
Component Test Code*Component Chart NameLOINC
2010215Renal Hereditary Cancer Panel Specimen31208-2
2010218Renal Hereditary Cancer Panel Interp41103-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • 0051650 HNPCC/Lynch Syndrome (MLH1) Sequencing and Deletion/Duplication
  • 0051654 HNPCC/Lynch Syndrome (MSH2) Sequencing and Deletion/Duplication
  • 0051656 HNPCC/Lynch Syndrome (MSH6) Sequencing and Deletion/Duplication
  • 2002470 PTEN-Related Disorders (PTEN) Sequencing and Deletion/Duplication
  • 2002965 von Hippel-Lindau (VHL) Sequencing and Deletion/Duplication
  • 2007167 Hereditary Paraganglioma-Pheochromocytoma (SDHB, SDHC, and SDHD) Sequencing and Deletion/Dup
  • 2009313 Li-Fraumeni (TP53) Sequencing and Deletion/Duplication
  • BAP1, FH, FLCN, MET, MLH1, MSH2, MSH6, PTEN, SDHB, SDHC, SDHD, TP53, TSC1, TSC2, VHL
  • Birt-Hogg-Dube syndrome
  • Cowden syndrome
  • Tuberous sclerosis (TS)