Gastrointestinal Hereditary Cancer Panel, Sequencing and Deletion/Duplication, 15 Genes
2010198
Ordering Recommendation
Confirm a diagnosis of hereditary gastrointestinal (GI) cancer in individuals with a personal or family history of GI cancer and/or polyposis.
Submit With Order
Mnemonic
GICAPAN
Methodology
Massive Parallel Sequencing/Exonic Oligonucleotide-based CGH Microarray
Performed
Varies
Reported
10-12 weeks
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
 
Collect
Lavender (EDTA) or yellow (ACD Solution A or B).  
Specimen Preparation
Transport 3 mL whole blood. (Min: 1 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
 
Remarks
 
Stability
Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable  
Reference Interval
By report
Interpretive Data
Refer to report.



Counseling and informed consent are recommended for genetic testing. Consent forms are available online at www.aruplab.com.

See Compliance Statement C: www.aruplab.com/CS
Note
CPT Code(s)
81201 (APC), 81203 (APC), 81292 (MLH1), 81294 (MLH1), 81295 (MSH2), 81297 (MSH2), 81298 (MSH6), 81300 (MSH6), 81321 (PTEN), 81323 (PTEN), 81403 (EPCAM), 81404 x3 (SDHC, SDHD, STK11), 81405 x5 (SDHB, SDHC, SMAD4, STK11, TP53), 81406 x3 (CDH1, MUTYH, SMAD4), 81479 x2
Components
Component Test Code*Component Chart Name
2010199Gastrointestinal Cancer Panel - Spcmn
2010202Gastrointestinal Cancer Panel - Interp
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Cross References
  • 0051650 HNPCC/Lynch Syndrome (MLH1) Sequencing and Deletion/Duplication
  • 0051654 HNPCC/Lynch Syndrome (MSH2) Sequencing and Deletion/Duplication
  • 0051656 HNPCC/Lynch Syndrome (MSH6) Sequencing and Deletion/Duplication
  • 2001971 Juvenile Polyposis (SMAD4) Sequencing and Deletion/Duplication
  • 2002470 PTEN-Related Disorders (PTEN) Sequencing and Deletion/Duplication
  • 2004915 Familial Adenomatous Polyposis Panel: (APC) Sequencing and Deletion/Duplication, (MUTYH) 2 M
  • 2004992 Juvenile Polyposis Syndrome (BMPR1A) Sequencing and Deletion/Duplication
  • 2006191 MUTYH-Associated Polyposis (MUTYH) Sequencing
  • 2007167 Hereditary Paraganglioma-Pheochromocytoma (SDHB, SDHC, and SDHD) Sequencing and Deletion/Dup
  • 2008398 Peutz-Jeghers Syndrome (STK11) Sequencing and Deletion/Duplication
  • 2009313 Li-Fraumeni (TP53) Sequencing and Deletion/Duplication
  • APC, BMPR1A, CDH1, EPCAM, MLH1, MSH2, MSH6, MUTYH, PTEN, SDHB, SDHC, SDHD, SMAD4, STK11, TP53
  • Cowden syndrome
  • familial adenomatous polyposis (FAP)
  • MUTYH-associated polyposis (MAP)