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Endocrine Hereditary Cancer Panel, Sequencing and Deletion/Duplication, 13 Genes
2010193
Ordering Recommendation

Confirm suspected hereditary endocrine cancer syndrome in individuals with personal or family history of endocrine cancer.

Mnemonic
ENDCAPAN
Methodology
Massively Parallel Sequencing/Exonic Oligonucleotide-based CGH Microarray
Performed
Varies
Reported
10-12 weeks
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
 
Collect
Lavender (EDTA) or yellow (ACD Solution A or B). 
Specimen Preparation
Transport 3 mL whole blood. (Min: 1 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
 
Remarks
 
Stability
Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable 
Reference Interval
By report
Interpretive Data
Refer to report.

Compliance Statement C: The performance characteristics of this test were validated by ARUP Laboratories. The U.S. Food and Drug Administration (FDA) has not approved or cleared this test. However, FDA approval or clearance is currently not required for clinical use of this test. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. ARUP is authorized under Clinical Laboratory Improvement Amendments (CLIA) and by all states to perform high-complexity testing. Counseling and informed consent are recommended for genetic testing. Consent forms are available online.

Note
CPT Code(s)
81437; 81438
Components
Component Test Code*Component Chart NameLOINC
2010194Endocrine Hered. Cancer Panel Specimen31208-2
2010197Endocrine Hereditary Cancer Panel Interp41103-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • 0051390 Multiple Endocrine Neoplasia Type 2 (MEN2), RET Gene Mutations by Sequencing
  • 2002470 PTEN-Related Disorders (PTEN) Sequencing and Deletion/Duplication
  • 2002965 von Hippel-Lindau (VHL) Sequencing and Deletion/Duplication
  • 2004863 Familial Adenomatous Polyposis (APC) Sequencing
  • 2005360 Multiple Endocrine Neoplasia Type1 (MEN1) Sequencing and Deletion/Duplication
  • 2007167 Hereditary Paraganglioma-Pheochromocytoma (SDHB, SDHC, and SDHD) Sequencing and Deletion/Dup
  • 2008398 Peutz-Jeghers Syndrome (STK11) Sequencing and Deletion/Duplication
  • 2009313 Li-Fraumeni (TP53) Sequencing and Deletion/Duplication
  • CDKN1B, MAX, MEN1, PTEN, RET, SDHAF2, SDHB, SDHC, SDHD, STK11, TMEM127, TP53, VHL
  • Cowden syndrome
  • medullary thyroid carcinoma (MTC)
  • MEN2A