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Central Nervous System Hereditary Cancer Panel, Sequencing and Deletion/Duplication, 15 Genes
2010188
Ordering Recommendation
Confirm suspected hereditary CNS cancer in individual with personal or family history of hereditary cancer. This test will not detect pathogenic PHOX2B polyalanine expansions causative for congenital hypoventilation syndrome.
Mnemonic
CNSCAPAN
Methodology
Massively Parallel Sequencing/Exonic Oligonucleotide-based CGH Microarray
Performed
Varies
Reported
10-12 weeks
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
 
Collect
Lavender (EDTA) or yellow (ACD Solution A or B).  
Specimen Preparation
Transport 3 mL whole blood. (Min: 1 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
 
Remarks
 
Stability
Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable  
Reference Interval
By report
Interpretive Data
Refer to report.


Compliance Statement C: The performance characteristics of this test were validated by ARUP Laboratories. The U.S. Food and Drug Administration (FDA) has not approved or cleared this test; however, FDA approval or clearance is currently not required for clinical use of this test. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. ARUP is authorized under Clinical Laboratory Improvement Amendments (CLIA) and by all states to perform high-complexity testing.

Counseling and informed consent are recommended for genetic testing. Consent forms are available online.
Note
CPT Code(s)
81201 (APC); 81203 (APC); 81292 (MLH1); 81294 (MLH1); 81295 (MSH2); 81297 (MSH2); 81298 (MSH6); 81300 (MSH6); 81321 (PTEN); 81323 (PTEN); 81403 x2 (PHOX2B, VHL); 81404 x3 (PHOX2B, STK11, VHL); 81405 x3 (NF2, STK11, TP53); 81406 (NF2); 81479 x2
Components
Component Test Code*Component Chart NameLOINC
2010189Central Nervous System Cancer Panel Spec31208-2
2010192Central Nervous System Cancer Pan Intrp41103-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • 0051650 HNPCC/Lynch Syndrome (MLH1) Sequencing and Deletion/Duplication
  • 0051654 HNPCC/Lynch Syndrome (MSH2) Sequencing and Deletion/Duplication
  • 0051656 HNPCC/Lynch Syndrome (MSH6) Sequencing and Deletion/Duplication
  • 2002470 PTEN-Related Disorders (PTEN) Sequencing and Deletion/Duplication
  • 2002965 von Hippel-Lindau (VHL) Sequencing and Deletion/Duplication
  • 2004863 Familial Adenomatous Polyposis (APC) Sequencing
  • 2008398 Peutz-Jeghers Syndrome (STK11) Sequencing and Deletion/Duplication
  • 2009313 Li-Fraumeni (TP53) Sequencing and Deletion/Duplication
  • ALK, APC, BAP1, MLH1, MSH2, MSH6, NF2, PHOX2B, PTEN, RB1, SMARCB1, STK11, SUFU, TP53, VHL
  • CNS tumor
  • Cowden syndrome