Central Nervous System Hereditary Cancer Panel, Sequencing and Deletion/Duplication, 15 Genes
2010188
Ordering Recommendation
Confirm suspected hereditary CNS cancer in individual with personal or family history of hereditary cancer.
Mnemonic
CNSCAPAN
Methodology
Massive Parallel Sequencing/Exonic Oligonucleotide-based CGH Microarray
Performed
Varies
Reported
10-12 weeks
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
 
Collect
Lavender (EDTA) or yellow (ACD Solution A or B).  
Specimen Preparation
Transport 3 mL whole blood. (Min: 1 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
 
Remarks
 
Stability
Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable  
Reference Interval
By report
Interpretive Data
Refer to report.



Counseling and informed consent are recommended for genetic testing. Consent forms are available online at www.aruplab.com.

See Compliance Statement C: www.aruplab.com/CS
Note
CPT Code(s)
81201 (APC), 81203 (APC), 81292 (MLH1), 81294 (MLH1), 81295 (MSH2), 81297 (MSH2), 81298 (MSH6), 81300 (MSH6), 81321 (PTEN), 81323 (PTEN), 81403 x2 (PHOX2B, VHL); 81404 x3 (PHOX2B, STK11, VHL), 81405 x3 (NF2, STK11, TP53); 81406 (NF2), 81479 x2
Components
Component Test Code*Component Chart Name
2010189Central Nervous System Cancer Panel Spec
2010192Central Nervous System Cancer Pan Intrp
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Cross References
  • 0051650 HNPCC/Lynch Syndrome (MLH1) Sequencing and Deletion/Duplication
  • 0051654 HNPCC/Lynch Syndrome (MSH2) Sequencing and Deletion/Duplication
  • 0051656 HNPCC/Lynch Syndrome (MSH6) Sequencing and Deletion/Duplication
  • 2002470 PTEN-Related Disorders (PTEN) Sequencing and Deletion/Duplication
  • 2002965 von Hippel-Lindau (VHL) Sequencing and Deletion/Duplication
  • 2004863 Familial Adenomatous Polyposis (APC) Sequencing
  • 2008398 Peutz-Jeghers Syndrome (STK11) Sequencing and Deletion/Duplication
  • 2009313 Li-Fraumeni (TP53) Sequencing and Deletion/Duplication
  • ALK, APC, BAP1, MLH1, MSH2, MSH6, NF2, PHOX2B, PTEN, RB1, SMARCB1, STK11, SUFU, TP53, VHL
  • CNS tumor
  • Cowden syndrome