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Phosphatidylserine and Prothrombin Antibodies, IgG and IgM
2009451
Ordering Recommendation

May be useful as an independent risk marker for thrombosis associated with APS and related diseases. Consider using when all criteria aPL antibody tests are negative; positive results should be reported to document persistence.

Mnemonic
APS/PT PAN
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Thu
Reported
1-8 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum separator tube. Also acceptable: Blue (sodium citrate). 
Specimen Preparation
Transfer 0.5 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.15 mL) 
Storage/Transport Temperature
Refrigerated. Also acceptable: Frozen. 
Unacceptable Conditions
Other body fluids. Contaminated, hemolyzed, grossly icteric, or severely lipemic specimens. 
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles) 
Reference Interval
Available
Separately
ComponentReference Interval
2009448Phosphatidylserine and Prothrombin IgG0-30 Units
NoPhosphatidylserine and Prothrombin IgM0-30 Units

Interpretive Data
The presence of elevated and persistent aPS/PT IgG and IgM antibodies (with or without lupus anticoagulant activity) may serve as a risk marker of thrombotic events in patients with certain autoimmune diseases, including antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). Strong clinical correlation is recommended for isolated IgM aPS/PT antibody.

Note
CPT Code(s)
83516 x2
Components
Component Test Code*Component Chart NameLOINC
2009448Phosphatidylserine and Prothrombin IgG
2009450Phosphatidylserine and Prothrombin IgM
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases