MYD88 L265P Mutation Detection by PCR, Quantitative
2009318
Ordering Recommendation
• Useful in distinguishing lymphoplasmacytic lymphoma (LPL) from other low-grade B-cell lymphoproliferative disorders which may be in the differential diagnosis.
• Use when monitoring patients with LPL diagnosis and previously identified MYD88 L265P mutation.
Mnemonic
MYD88
Methodology
Real-time Polymerase Chain Reaction
Performed
DNA isolation: Sun-Sat
Testing: Varies
Reported
7-10 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Lavender (EDTA) OR bone marrow (EDTA) OR tissue.  
Specimen Preparation
Whole Blood: Transport 5 mL (Min: 1 mL)
Bone marrow:
Transport 3 mL (Min: 1 mL)
FFPE tumor tissue:
Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Protect from excessive heat. Transport tissue in a tissue transport kit (ARUP Supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787.  
Storage/Transport Temperature
Whole blood OR Bone marrow: Refrigerated.
FFPE tumor tissue:
Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months.  
Unacceptable Conditions
Serum or plasma. Specimens collected in anticoagulants other than EDTA. Clotted or severely hemolyzed specimens.
FFPE tumor tissue:
Specimens fixed/processed in alternative fixatives or heavy metal fixatives (B-4 or B-5) or tissue sections on slides. Decalcified specimens.  
Remarks
  
Stability
Whole blood OR Bone marrow: Ambient: 24 hours; Refrigerated: 5 days; Frozen: Unacceptable
FFPE tumor tissue:
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable  
Reference Interval
   
Interpretive Data
Refer to report.

See Compliance Statement B: www.aruplab.com/CS  
Note
 
CPT Code(s)
81479
Components
Component Test Code*Component Chart Name
2009319MYD88 Source
2009320MYD88 L265P Detection, Result
2009321MYD88 L265P Detection, Quant
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Aliases
  • Lymphoplasmacytic lymphoma
  • Waldenstrom macroglobulinemia