Streptococcus pneumoniae Antibodies, IgG (9 Serotypes)
2008919
Ordering Recommendation
Submit With Order
Mnemonic
PNEUMO 9
Methodology
Quantitative Multiplex Bead Assay
Performed
Tue, Fri
Reported
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
 
Collect
Serum separator tube. Post-immunization specimen should be drawn 30 days after immunization and, if shipped separately, must be received within 60 days of pre-immunization specimen.  
Specimen Preparation
Separate serum from cells within 2 hours of collection. Transfer 1.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.25 mL) MARK SPECIMENS CLEARLY AS "PRE" OR "POST" SO SPECIMENS WILL BE SAVED AND TESTED SIMULTANEOUSLY.  
Storage/Transport Temperature
Refrigerated. "Pre" and "post" pneumococcal vaccine specimens can be submitted separately or together for testing.  
Unacceptable Conditions
Plasma or other body fluids. Contaminated, hemolyzed, or severely lipemic specimens.  
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
Interpretive Data
A pre- and post- vaccination sample comparison is required in order to assess the humoral immune response to vaccination with Streptococcus pneumonia vaccine. Post vaccination samples should be obtained at 4 weeks post-immunization. A single sample provides only general immune status of an individual to various serotypes of pneumococci. Immune response to pneumococci may vary in different individuals based on the age, vaccination status, immunologic competence and the serotype of the organism. Long-term protection is generally considered to be a serotype antibody level of 1.3 µg/ mL or greater.

Following vaccination, an antibody ratio of less than twofold is considered a non-responder; a ratio of two- to fourfold is a weak responder; a ratio of fourfold or greater is a good responder. The higher the pre-vaccination antibody level for a specific pneumococcal serotype, the less likely the response will increase significantly after vaccination.

An increased antibody level to 50-70 percent or more of the serotypes is thought to represent a normal humoral response. In the case of pure polysaccharide vaccine, indication of immune system competence is further delineated as an adequate response to at least 70 percent of the serotypes in the vaccine challenge for those 6-65 years of age, or to at least 50 percent of the serotypes in the vaccine challenge for those 2-5 years of age.
µµ

See Compliance Statement B: www.aruplab.com/CS
Note
Includes Serotypes 2, 10A, 11A, 15B, 17F, 19A, 20, 22F, and 33F. (Conjugated Serotypes: 19A.).

This assay is designed to use both pre- and post-immunization specimens to assess immune responsiveness to pneumococcal vaccine. This test is not designed to determine protection to Streptococcus pneumoniae based on a single specimen.
CPT Code(s)
86317 x9
Components
Component Test Code*Component Chart Name
0050719Pneumo Serotype Interpretation
2005780Pneumococcal Serotype 2 IgG
2005781Pneumococcal Serotype 10A IgG
2005782Pneumococcal Serotype 11A IgG
2005783Pneumococcal Serotype 15B IgG
2005784Pneumococcal Serotype 17F IgG
2005785Pneumococcal Serotype 19A IgG
2005786Pneumococcal Serotype 20 IgG
2005787Pneumococcal Serotype 22F IgG
2005788Pneumococcal Serotype 33F IgG
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Cross References