Lung Cancer Panel
2008894
Ordering Recommendation
Screening panel to determine eligibility for TKIs. EGFR, ALK, and ROS1 genes tested; EGFR by Pyrosequencing and ALK and ROS1 by IHC. To include KRAS by PCR, refer to Lung Cancer Panel with KRAS 2008895.
Mnemonic
LUNG PANEL
Methodology
Polymerase Chain Reaction/Pyrosequencing/Immunohistochemistry
Performed
Varies
Reported
12-14 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Tumor tissue.  
Specimen Preparation
Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Protect from excessive heat. Transport tissue block or 13 unstained 5-micron slides (8 on positively charged slides AND 5 on uncharged slides). (Min: 9 slides: 5 positively charged AND 4 uncharged) Tissue block will be returned after testing. Transport block and/or slide(s) in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect or contact ARUP Client Services at (800) 522-2787.  
Storage/Transport Temperature
Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months.  
Unacceptable Conditions
Less than 25 percent tumor. Specimens fixed/processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives. Decalcified specimens.  
Remarks
Include surgical pathology report.  
Stability
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable  
Reference Interval
   
Interpretive Data
Refer to report.

See Compliance Statement A: www.aruplab.com/CS
Statement A: Analyte specific reagents (ASR) are used in many laboratory tests necessary for standard medical care and generally do not require U.S. Food and Drug Administration (FDA) approval or clearance. This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. This test should not be regarded as investigational or for research use.
 
Note
Panel consists of EGFR Mutation Detection by Pyrosequencing, ALK (D5F3) with Interpretation by Immunohistochemistry, and ROS1 with Interpretation by Immunohistochemistry with Reflex to FISH if Equivocal. If reflexed, additional charges apply.
CPT Code(s)
88381, 81235, 88360 x2, if reflexed add 88367
Components
Component Test Code*Component Chart NameLOINC
2002148Block ID57723-9
2002442EGFR by Pyrosequencing21665-5
2007325ALK(D5F3) by IHC Reference Number30896-5
2007326ALK(D5F3) by IHC Pct of Tumor Staining 
2007327ALK(D5F3) by IHC Result35474-6
2008415ROS1 by IHC Result 
2008417ROS1 Client Block ID 
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases