T-Cell Clonality by Next Generation Sequencing
Ordering Recommendation

Diagnosis and monitoring of T-cell lymphoproliferative disorders. It is the preferred T-cell clonality test for minimal residual disease monitoring due to its ability to detect clonal populations at very low levels.

Massively Parallel Sequencing
Sun, Tue, Thu
7-10 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Whole blood: Lavender (EDTA). OR Bone marrow: EDTA. OR Tissue.  
Specimen Preparation
Whole blood: Transport 5 mL whole blood. (Min: 1 mL)
OR Bone marrow:
Transport 3 mL bone marrow. (Min: 1 mL)
OR Fresh tissue:
Freeze immediately. Transport 100 mg or 0.5-2.0 cm3 tissue.
OR FFPE tumor tissue:
Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Protect from excessive heat. Transport tissue block or four 10-micron shavings. Tissue block will be returned after testing. Transport tissue (frozen or paraffin) in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect or contact ARUP Client Services at (800) 522-2787.  
Storage/Transport Temperature
Whole blood OR Bone marrow: Refrigerated.  
Fresh tissue:
Frozen on dry ice.
FFPE tumor tissue:
Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months.  
Unacceptable Conditions
Serum. Frozen whole blood or bone marrow. Clotted or grossly hemolyzed specimens. Specimens fixed/processed in alternative fixatives or heavy metal fixatives (B-4 or B-5) or tissue sections on slides. Decalcified specimens.  
Whole blood OR Bone marrow: Ambient: 24 hours; Refrigerated: 5 days; Frozen: Unacceptable
Fresh Tissue:
Ambient: Unacceptable; Refrigerated: 2 hours; Frozen: 1 year
FFPE tumor tissue:
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable  
Reference Interval
Interpretive Data
Refer to report.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
CPT Code(s)
Component Test Code*Component Chart NameLOINC
2008410T-Cell Clonality Specimen Source31208-2
2008411T-Cell Clonality Interpretation21753-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • T Cell Gamma
  • T Cell Gene Rearrangement
  • T-cell receptor gamma rearrangement
  • T-Cell Receptor Gene Rearrangement
  • tcell clonality
  • Tcell next gen
  • TCRG