Benzodiazepines - Confirmation/Quantitation - Urine
Ordering Recommendation
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
1-4 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Random urine.  
Specimen Preparation
Transfer 0.5 mL urine with no additives or preservatives to an ARUP Standard Transport Tube. (Min: 0.3 mL)  
Storage/Transport Temperature
Room temperature.  
Unacceptable Conditions
Specimens exposed to repeated freeze/thaw cycles.  
Ambient: 1 week; Refrigerated: 1 month; Frozen: 3 years  
Reference Interval
Interpretive Data
Methodology: Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Drugs covered:
alprazolam, alpha-hydroxyalprazolam, chlordiazepoxide, clonazepam, 7-amino-clonazepam, desalkylflurazepam, 2-hydroxyethylflurazepam, diazepam, lorazepam, midazolam, alpha-hydroxymidazolam, nordiazepam, oxazepam, prazepam, temazepam, alpha-hydroxytriazolam, and zolpidem.

Positive cutoff:
20 ng/mL unless specified below:
Alprazolam 5 ng/mL
Alpha-hydroxyalprazolam 5 ng/mL
Clonazepam 5 ng/mL
7-aminoclonazepam 5 ng/mL

For medical purposes only; not valid for forensic use.

The absence of expected drug(s) and/or drug metabolite(s) may indicate non-compliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, diluted/adulterated urine, or limitations of testing. The concentration value must be greater than or equal to the cutoff to be reported as positive. Interpretive questions should be directed to the laboratory.

See Compliance Statement B:
Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
CPT Code(s)
Component Test Code*Component Chart Name
0090358Benzodiazepine, Urine, Interpretation
2007834Diazepam, Urine
2007835Oxazepam, Urine
2007836Temazepam, Urine
2007837Nordiazepam, Urine
2007838Lorazepam, Urine
2007839Alprazolam, Urine
2007840Alpha-hydroxyalprazolam, Urine
2007841Clonazepam, Urine
20078427-aminoclonazepam, Urine
2007843Alpha-hydroxytriazolam, Urine
20078442-hydroxyethylflurazepam, Urine
2007845Desalkylflurazepam, Urine
2007846Midazolam, Urine
2007847Chlordiazepoxide, Urine
2007849Prazepam, Urine
2007850Zolpidem, Urine
2008511Alpha-hydroxymidazolam, Urine
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
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