Motor and Sensory Neuropathy Evaluation with Immunofixation Electrophoresis and Reflex to Titer and Neuronal Immunoblot
2007967
Ordering Recommendation
 
Mnemonic
MSNCR
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Indirect Fluorescent Antibody/Qualitative Immunoblot/Quantitative Nephelometry/Quantitative Capillary Electrophoresis/Qualitative Immunofixation Electrophoresis
Performed
Refer to individual components
Reported
3-9 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Serum separator tube  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 4 mL serum to an ARUP Standard Transport Tube. (Min: 2 mL)  
Storage/Transport Temperature
Refrigerated  
Unacceptable Conditions
Plasma, CSF, or other body fluids. Contaminated, heat-inactivated, hemolyzed, severely icteric, or lipemic specimens.  
Remarks
  
Stability
Ambient: Unacceptable; Refrigerated: 2 weeks; Frozen: 1 year  
Reference Interval
 
 
Test Number Components Reference Interval
 Purkinje Cell/Neuronal Nuclear IgG Scrn None Detected
 Neuronal Nuclear Antibody (ANNA) IFA Titer, IgG Less than 1:10
 Purkinje Cell Antibody, Titer Less than 1:10
2007963Neuronal Nuclear Antibodies (Hu, Ri, Yo) IgG by Immunoblot None Detected
0051285Myelin Associated Glycoprotein (MAG) Antibody, IgM Less than 1000 TU
0051284Sulfate-​3-​Glucuronyl Paragloboside (SGPG) Antibody, IgM Less than 1.00 IV
 Asialo-​GM1 Antibodies, IgG/IgM 29 IV or less: Negative
30-​50 IV: Equivocal
51-​100 IV: Positive
101 IV or greater: Strong Positive
 GM1 Antibodies, IgG/IgM 29 IV or less: Negative
30-​50 IV: Equivocal
51-​100 IV: Positive
101 IV or greater: Strong Positive
 GD1a Antibodies, IgG/IgM 29 IV or less: Negative
30-​50 IV: Equivocal
51-​100 IV: Positive
101 IV or greater: Strong Positive
 GD1b Antibodies, IgG/IgM 29 IV or less: Negative
30-​50 IV: Equivocal
51-​100 IV: Positive
101 IV or greater: Strong Positive
 GQ1b Antibodies, IgG/IgM 29 IV or less: Negative
30-​50 IV: Equivocal
51-​100 IV: Positive
101 IV or greater: Strong Positive
 Total Protein-​Electrophoresis, Serum 6.00-​8.30 g/dL
 Albumin 3.75-​5.01 g/dL
 Alpha-​1 Globulins 0.19-​0.46 g/dL
 Alpha-​2 Globulins 0.48-​1.05 g/dL
 Beta Globulins 0.48-​1.10 g/dL
 Gamma 0.62-​1.51 g/dL
0050340Immunoglobulin A  
 
0-​30 days: 1-​7 mg/dL
1 month: 1-​53 mg/dL
2 months: 3-​47 mg/dL
3 months: 5-​46 mg/dL
4 months: 4-​72 mg/dL
5 months: 8-​83 mg/dL
6 months: 8-​67 mg/dL
7-​8 months: 11-​89 mg/dL
9-​11 months: 16-​83 mg/dL
1 year: 14-​105 mg/dL
2 years: 14-​122 mg/dL
3 years: 22-​157 mg/dL
4 years: 25-​152 mg/dL
5-​7 years: 33-​200 mg/dL
8-​9 years: 45-​234 mg/dL
10 years and older: 68-​378 mg/dL
0050350Immunoglobulin G  
 
0-​ 30 days: 611-​1542 mg/dL             
1 month: 241-​870 mg/dL                         
2 months: 198-​577 mg/dL           
3 months: 169-​558 mg/dL                   
4 months: 188-​536 mg/dL                         
5 months: 165-​781 mg/dL                         
6 months: 206-​676 mg/dL                           
7-​8 months: 208-​868 mg/dL                       
9-​11 months: 282-​1026 mg/dL
1 year: 331-​1164 mg/dL
2 years: 407-​1009 mg/dL
3 years: 423-​1090 mg/dL
4 years: 444-​1187 mg/dL
5-​7 years: 608-​1229 mg/dL
8-​9 years: 584-​1509 mg/dL
10 years and older: 768-​1632 mg/dL
0050355Immunoglobulin M  
 
0-​30 days: 0-​24 mg/dL                     
1 month: 19-​83 mg/dL                               
2 months: 16-​100 mg/dL                         
3 months: 23-​85 mg/dL                               
4 months: 26-​96 mg/dL                             
5 months: 31-​103 mg/dL                           
6 months: 33-​97 mg/dL                               
7-​8 months: 32-​120 mg/dL                         
9-​11 months: 39-​142 mg/dL
1 year: 41-​164 mg/dL
2 years: 46-​160 mg/dL
3 years: 45-​190 mg/dL
4 years: 41-​186 mg/dL
5-​7 years: 46-​197 mg/dL
8-​9 years: 49-​230 mg/dL
10 years and older: 60-​263 mg/dL
Interpretive Data


See Compliance Statement D: www.aruplab.com/CS
Statement D: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
 
Note
PCCA/ANNA antibodies are screened by IFA. If the IFA screen is positive at 1:10 or greater, then a titer (PCCA or ANNA) and Immunoblot will be added. Additional charges apply.
CPT Code(s)
83516 x 7; 84160; 82784 x3; 84165; 86334; ; 86255; if reflexed add 86256 and 83516
Components
Component Test Code*Component Chart Name
0050020Albumin
0050035Alpha 1 Globulin
0050060Alpha 2 Globulin
0050110Beta Globulin
0050270Gamma
0050271Immunofixation
0050340Immunoglobulin A
0050350Immunoglobulin G
0050355Immunoglobulin M
0050545Total Protein-Electrophoresis
0051034Asialo-GM1 Antibodies, IgG/IgM
0051035GM1 Antibodies, IgG/IgM
0051037GD1a Antibodies, IgG/IgM
0051038GD1b Antibodies, IgG/IgM
0051039GQ1b Antibodies, IgG/IgM
0051284SGPG Antibody, IgM
0051285MAG Antibody, IgM Elisa
2005168SPEP/IFE Interpretation
2007962Purkinje Cell/Neuronal Nuclear IgG Scrn
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Aliases