Sensory Neuropathy Antibody Panel with Reflex to Titer and Neuronal Immunoblot
Ordering Recommendation

Aid in diagnosis of a sensory neuropathy when malignancy, other than plasma cell dyscrasia, is suspected.

Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Indirect Fluorescent Antibody/Qualitative Immunoblot
Refer to individual components
2-9 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Serum separator tube 
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Other body fluids. Contaminated, heat-inactivated, hemolyzed, grossly icteric, or lipemic specimens. 
After separation from cells: Ambient: 24 hours; Refrigerated: 2 weeks; Frozen: 1 year 
Reference Interval
Test Number
Reference Interval
Purkinje Cell/Neuronal Nuclear IgG ScrnNone Detected
Neuronal Nuclear Antibody (ANNA) IFA Titer, IgGLess than  1:10
Purkinje Cell Antibody, TiterLess than  1:10
2007963Neuronal Nuclear Antibodies (Hu, Ri, Yo) IgG by ImmunoblotNone Detected
0051285Myelin Associated Glycoprotein (MAG) Antibody, IgMLess than 1000 TU
0051284Sulfate-3-Glucuronyl Paragloboside (SGPG) Antibody, IgMLess than 1.00 IV

Interpretive Data

Compliance Statement D: For laboratory tests using a manufactured RUO kit. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Purkinje Cell (PCCA) antibody and Neuronal Nuclear (ANNA) antibody IgG are screened by IFA. If the IFA screen is indeterminate, then a Neuronal Nuclear Antibodies (Hu, Ri, and Yo) IgG by Immunoblot will be added. If the IFA screen is positive at 1:10 or greater, then a PCCA/ANNA antibodies titer and Neuronal Nuclear Antibodies (Hu, Ri, and Yo) IgG by Immunoblot will be added. Additional charges apply.
Hotline History
CPT Code(s)
83516 x2; 86255; if reflexed add 83516 and/or 86256
Component Test Code*Component Chart NameLOINC
0051284SGPG Antibody, IgM31666-1
0051285MAG Antibody, IgM Elisa17314-6
2007962Purkinje Cell/Neuronal Nuclear IgG Scrn61177-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • ANNA IgG
  • MAG IgM
  • Neuronal Nucelar IgG Abs
  • Purkinje Cell IgG Screen
  • Purkinje Cell Titer
  • SGPG IgM