Neuronal Nuclear (Hu, Ri, and Yo) Antibodies IgG by Western Blot
2007963
Ordering Recommendation
Submit With Order
Mnemonic
NRNL IB
Methodology
Qualitative Western Blot
Performed
Thu
Reported
1-8 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
 
Collect
Serum separator tube  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL)  
Storage/Transport Temperature
Refrigerated  
Unacceptable Conditions
Plasma. Contaminated, heat-inactivated, hemolyzed, or lipemic specimens  
Remarks
 
Stability
After separation from cells: Ambient: 24 hours; Refrigerated: 2 weeks; Frozen: 1 year  
Reference Interval
None Detected
Interpretive Data
This test detects IgG antineuronal antibodies to Hu, Ri, and Yo antigens. Only the antibodies detected are reported in the result field.

Antineuronal antibodies serve as markers that aid in discriminating between a true paraneoplastic neurological disorder (PND) and other inflammatory disorders of the nervous system. Anti-Hu (antineuronal nuclear antibody, type I) is associated with small-cell lung cancer. Anti-Ri (antineuronal nuclear antibody, type II) is associated with neuroblastoma in children and with fallopian tube and breast cancer in adults. Anti-Yo (anti-Purkinje cell cytoplasmic antibody) is associated with ovarian and breast cancer.

The presence of one or more of these antineuronal antibodies supports a clinical diagnosis of PND and should lead to a focused search for the underlying neoplasm.

See Compliance Statement D: www.aruplab.com/CS
Note
CPT Code(s)
83516
Components
Component Test Code*Component Chart Name
2007964Neuronal Nuclear Abs IgG, Western Blot
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Cross References
  • Hu, Ri, and Yo Ab
  • Neuronal Ab Wb
  • Neuronal Nuclear Ab IgG