Aids in discriminating between a paraneoplastic neurologic syndrome and other encephalitis of unknown origin.
- Patient Preparation
- Serum separator tube
- Specimen Preparation
- Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL)
- Storage/Transport Temperature
- Unacceptable Conditions
- Plasma. Contaminated, heat-inactivated, hemolyzed, or lipemic specimens
- After separation from cells: Ambient: 24 hours; Refrigerated: 2 weeks; Frozen: 1 year
Antineuronal antibodies serve as markers that aid in discriminating between a true paraneoplastic neurological disorder (PND) and other inflammatory disorders of the nervous system. Anti-Hu (antineuronal nuclear antibody, type I) is associated with small-cell lung cancer. Anti-Ri (antineuronal nuclear antibody, type II) is associated with neuroblastoma in children and with fallopian tube and breast cancer in adults. Anti-Yo (anti-Purkinje cell cytoplasmic antibody) is associated with ovarian and breast cancer.
The presence of one or more of these antineuronal antibodies supports a clinical diagnosis of PND and should lead to a focused search for the underlying neoplasm.
|Component Test Code*||Component Chart Name||LOINC|
|2007964||Neuronal Nuclear Abs IgG, Immunoblot||35278-1|
- Hu, Ri, and Yo Ab
- Neuronal Ab Immunoblot
- Neuronal Nuclear Ab IgG