Paraneoplastic Antibodies (PCCA/ANNA) by IFA with Reflex to Titer and Immunoblot
2007961
Ordering Recommendation
Aid in the diagnosis of  paraneoplastic neurologic syndromes associated with malignancy. Order based on clinical presentation. PCCA/ANNA antibodies are screened by IFA; if IFA screen is positive, a specific titer (PCCA or ANNA) and immunoblot will be added.
Mnemonic
PCCA/ANNA
Methodology
Semi-Quantitative Indirect Fluorescent Antibody/Qualitative Immunoblot
Performed
Wed
Reported
1-9 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Serum separator tube  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.75 mL)  
Storage/Transport Temperature
Refrigerated  
Unacceptable Conditions
Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.  
Remarks
  
Stability
After separation from cells: Ambient: 24 hours; Refrigerated: 2 weeks; Frozen: 1 year  
Reference Interval
 
 
Test Number Components Reference Interval
 Purkinje Cell/Neuronal Nuclear IgG Scrn None Detected
 Neuronal Nuclear Antibody (ANNA) IFA Titer, IgG Less than 1:10
 Purkinje Cell Antibody, Titer Less than 1:10
2007963Neuronal Nuclear Antibodies (Hu, Ri, Yo) IgG by Immunoblot None Detected
Interpretive Data


See Compliance Statement D: www.aruplab.com/CS
Statement D: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
 
Note
PCCA/ANNA antibodies are screened by IFA. If the IFA screen is positive at 1:10, then a specific titer (PCCA or ANNA) and Immunoblot will be added. Additional charges apply
CPT Code(s)
86255; if reflexed add 86256 and 83516
Components
Component Test Code*Component Chart NameLOINC
2007962Purkinje Cell/Neuronal Nuclear IgG Scrn61177-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • ANNA
  • ANNA-1
  • ANNA-2
  • Anti Ri
  • Anti-Hu
  • Anti-Yo
  • Antinuclear neuronal Ab
  • Neuronal Nuclear Antibody
  • Paraneoplastic Ab screen
  • Paraneoplastic Autoantibody Immunoblot Confirmation, Paraneoplastic Neurological Autoimmunity
  • PCA-1
  • Purkinje Cell Cytoplasmic Antibodies