Ziprasidone, Serum or Plasma
Ordering Recommendation
Therapeutic monitoring of ziprasidone (eg, Zeldox, Geodon).
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Sun, Wed
1-5 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Pre-dose (trough) draw - At steady state concentration.  
Lavender (EDTA), pink (K2EDTA) or plain red.  
Specimen Preparation
Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)  
Storage/Transport Temperature
Unacceptable Conditions
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).  
Submit With Order
Please indicate in the supplied fields:
1.  Dose - List drug amount and include the units of measure
2.  Route - List the route of administration (IV, oral, etc.)
3.  Dose Frequency - Indicate how often the dose is administered (per day, per week, as needed, etc.)
4.  Type of Draw - Indicate the type of blood draw (Peak, Trough, Random, etc.)  
Ambient: 2 weeks Refrigerated: 2 weeks; Frozen: 2 weeks  
Reference Interval
Therapeutic range Not well established
Proposed Dose-​Related Range 50-​200 ng/mL
Toxic range Not well established
Interpretive Data
Adverse effects to ziprasidone therapy may include headache, postural hypotension, tachycardia and dyskinesia.

See Compliance Statement B:
Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
CPT Code(s)
80342; (Alt code: 80299)
Component Test Code*Component Chart NameLOINC
2007956Ziprasidone Serum/Plasma33946-5
2011593Ziprasidone Dose 
2011594Ziprasidone Dose Frequency 
2011595Ziprasidone Route 
2011596Ziprasidone Type of Draw 
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
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