Human Papillomavirus (HPV), High Risk by Transcription-Mediated Amplification (TMA) with Reflex to HPV Genotypes 16 and 18/45 by TMA, ThinPrep
2007890
Ordering Recommendation
Use in conjunction with cytology for cervical cancer screening in women >=30. May be used in triaging women to colposcopy who are cytology-negative (NILM) and HPV-positive.
Mnemonic
HPV TMA GR
Methodology
Qualitative Transcription-Mediated Amplification
Performed
Tue, Thu, Sat
Reported
2-7 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Females should avoid high concentrations of antifungal cream or contraceptive jelly, and should not douche prior to time of collection.  
Collect
Cervical specimen with the ThinPrep Pap Test Collection kit.  
Specimen Preparation
Vortex ThinPrep PreservCyt solution and transfer 1 mL to an APTIMA Specimen Transfer Tube (ARUP supply #42711) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787.  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Specimens in any media other than indicated above.  
Remarks
Specimen source required.  
Stability
ThinPrep PreservCyt solution: Ambient: 1 month; Refrigerated: 1 month; Frozen: 2 years
APTIMA Specimen Transfer Tube: Ambient: 2 months; Refrigerated: 2 months; Frozen: 2 years  
Reference Interval
Negative  
Interpretive Data
This test detects E6/E7 viral messenger RNA of the high-risk HPV types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68 associated with cervical cancer and its precursor lesions. Cross-reactivity with low-risk HPV genotypes 26, 67, 70, and 82 may occur. Sensitivity may be affected by specimen collection methods, stage of infection, and the presence of interfering substances. Results should be interpreted in conjunction with other available laboratory and clinical data.

This test is intended for medical purposes only and is not valid for the evaluation of suspected sexual abuse or for other forensic purposes. HPV testing should not be used for screening or management of atypical squamous cells of undetermined significance (ASCUS) in women under age 21.

If Human Papillomavirus (HPV), High Risk is positive, then HPV genotypes 16, 18/45 will be added. Additional charges apply.  
Note
 
CPT Code(s)
87624; if reflexed add 87625 x2
Components
Component Test Code*Component Chart NameLOINC
0060752HPV Source31208-2
2007891HPV, High Risk by TMA49896-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • HPV genotype
  • HPV HR E6/E7 reflex to 16 and 18/45
  • HPV HR reflex to genotyping
  • HPV mRNA reflex
  • Nucleic Acid Amplification Test (NAAT)