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Antiphospholipid Antibodies Extended Panel (INACTIVE as of 01/04/16: Refer to November 2015 Hot Line for Replacement Tests: 2012729 OR 2012730, ACTIVE 01/04/16)
2007609
Ordering Recommendation
Mnemonic
PHOS EXT
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Refer to individual components
Reported
1-8 days
N/A
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Seum separator tube. 
Specimen Preparation
Separate serum from cells ASAP or within two hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.6 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Urine or plasma. Contaminated, heat-inactivated, severely hemolyzed, grossly icteric, or severely lipemic specimens. 
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles) 
Reference Interval
Test Number
Components
Reference Interval
 Phosphatidylserine Antibody IgGLess than 11 U/mL
 Phosphatidylserine Antibody IgMLess than  25 U/mL
 Phosphatidylethanolamine Antibody IgG0-11 U/mL: Normal
12-18 U/mL: Equivocal.  Suggest repeat testing in 4-6 weeks or consider antibody testing for cardiolipin IgG and IgM, beta-2 glycoprotein 1 IgG and IgM and lupus anticoagulant.
19 U/mL or greater: Positive
 Phosphatidylethanolamine Antibody IgM0-11 U/mL: Normal
12-18 U/mL: Equivocal.  Suggest repeat testing in 4-6 weeks or consider antibody testing for cardiolipin IgG and IgM, beta-2 glycoprotein 1 IgG and IgM and lupus anticoagulant.
19 U/mL or greater: Positive
 Phosphatidylinositol Antibody IgG0-11 U/mL: Normal
12-18 U/mL: Equivocal.  Suggest repeat testing in 4-6 weeks or consider antibody testing for cardiolipin IgG and IgM, beta-2 glycoprotein 1 IgG and IgM and lupus anticoagulant.
19 U/mL or greater: Positive
 Phosphatidylinositol Antibody IgM0-11 U/mL: Normal
12-18 U/mL: Equivocal.  Suggest repeat testing in 4-6 weeks or consider antibody testing for cardiolipin IgG and IgM, beta-2 glycoprotein 1 IgG and IgM and lupus anticoagulant.
19 U/mL or greater: Positive
 Phosphatidylcholine Ab, IgG0-11 U/mL: Normal
12-18 U/mL: Equivocal.  Suggest repeat testing in 4-6 weeks or consider antibody testing for cardiolipin IgG and IgM, beta-2 glycoprotein 1 IgG and IgM and lupus anticoagulant.
19 U/mL or greater: Positive
 Phosphatidylcholine Ab, IgM0-11 U/mL: Normal
12-18 U/mL: Equivocal.  Suggest repeat testing in 4-6 weeks or consider antibody testing for cardiolipin IgG and IgM, beta-2 glycoprotein 1 IgG and IgM and lupus anticoagulant.
19 U/mL or greater: Positive
 Phosphatidic Acid Antibody, IgG
Reference Interval
0-11 U/mLNormal
12-18 U/mLEquivocal. Suggest repeat testing in 4-6 weeks or consider antibody testing for cardiolipin IgG and IgM, beta-2 glycoprotein 1 IgG and IgM and lupus anticoagulant.
19 U/mL or greaterPositive

 Phosphatidic Acid Antibody, IgM
Reference Interval
0-11 U/mLNormal
12-18 U/mLEquivocal. Suggest repeat testing in 4-6 weeks or consider antibody testing for cardiolipin IgG and IgM, beta-2 glycoprotein 1 IgG and IgM and lupus anticoagulant.
19 U/mL or greaterPositive


Interpretive Data


Compliance Statement D: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
CPT Code(s)
86148 x2; 83516 x8
Components
Component Test Code*Component Chart NameLOINC
0050906Phosphatidylserine Antibody IgG32032-5
0050907Phosphatidylserine Antibody IgM32033-3
0051591Phosphatidylcholine Ab, IgG14008-7
0051592Phosphatidylcholine Ab, IgM14009-5
0051602Phosphatidylethanolamine Antibody IgG13076-5
0051603Phosphatidylethanolamine Antibody IgM13077-3
0051608Phosphatidylinositol Antibody IgG13082-3
0051609Phosphatidylinositol Antibody IgM13083-1
2007604Phosphatidic Acid Antibody, IgM13071-6
2007606Phosphatidic Acid Antibody, IgG13070-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • APS non-criteria panel
  • Non-Criteria Antiphospholipid
  • non-criteria APS