Antiphospholipid Antibodies Extended Panel
2007609
 
Ordering Recommendation
Acceptable second-line test for strong suspicion of antiphospholipid syndrome (APS) and negative aPL criteria tests.
Mnemonic
PHOS EXT
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Refer to individual components
Reported
1-8 days
N/A
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
 
Collect
Seum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within two hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.6 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Urine or plasma. Contaminated, heat-inactivated, severely hemolyzed, grossly icteric, or severely lipemic specimens.  
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
Test Number Components Reference Interval
Phosphatidylserine Antibody, IgG Less than 11 U/mL
Phosphatidylserine Antibody, IgM Less than 25 U/mL
Phosphatidylethanolamine Antibody, IgG 0-​11 U/mL: Normal
12-​18 U/mL: Equivocal. Suggest repeat testing in 4-​6 weeks or consider antibody testing for cardiolipin IgG and IgM, beta-​2 glycoprotein 1 IgG and IgM and lupus anticoagulant.
19 U/mL or greater: Positive
Phosphatidylethanolamine Antibody, IgM 0-​11 U/mL: Normal
12-​18 U/mL: Equivocal. Suggest repeat testing in 4-​6 weeks or consider antibody testing for cardiolipin IgG and IgM, beta-​2 glycoprotein 1 IgG and IgM and lupus anticoagulant.
19 U/mL or greater: Positive
Phosphatidylinositol Antibody, IgG 0-​11 U/mL: Normal
12-​18 U/mL: Equivocal. Suggest repeat testing in 4-​6 weeks or consider antibody testing for cardiolipin IgG and IgM, beta-​2 glycoprotein 1 IgG and IgM and lupus anticoagulant.
19 U/mL or greater: Positive
Phosphatidylinositol Antibody, IgM 0-​11 U/mL: Normal
12-​18 U/mL: Equivocal. Suggest repeat testing in 4-​6 weeks or consider antibody testing for cardiolipin IgG and IgM, beta-​2 glycoprotein 1 IgG and IgM and lupus anticoagulant.
19 U/mL or greater: Positive
Phosphatidylcholine Antibody, IgG 0-​11 U/mL: Normal
12-​18 U/mL: Equivocal. Suggest repeat testing in 4-​6 weeks or consider antibody testing for cardiolipin IgG and IgM, beta-​2 glycoprotein 1 IgG and IgM and lupus anticoagulant.
19 U/mL or greater: Positive
Phosphatidylcholine Antibody, IgM 0-​11 U/mL: Normal
12-​18 U/mL: Equivocal. Suggest repeat testing in 4-​6 weeks or consider antibody testing for cardiolipin IgG and IgM, beta-​2 glycoprotein 1 IgG and IgM and lupus anticoagulant.
19 U/mL or greater: Positive
Phosphatidic Acid Antibody, IgG
Reference Interval
0-​11 U/mL Normal
12-​18 U/mL Equivocal. Suggest repeat testing in 4-​6 weeks or consider antibody testing for cardiolipin IgG and IgM, beta-​2 glycoprotein 1 IgG and IgM and lupus anticoagulant.
19 U/mL or greater Positive
Phosphatidic Acid Antibody, IgM
Reference Interval
0-​11 U/mL Normal
12-​18 U/mL Equivocal. Suggest repeat testing in 4-​6 weeks or consider antibody testing for cardiolipin IgG and IgM, beta-​2 glycoprotein 1 IgG and IgM and lupus anticoagulant.
19 U/mL or greater Positive
Interpretive Data


See Compliance Statement D: www.aruplab.com/CS
Note
CPT Code(s)
86148 x2, 83516 x8
Components
Component Test Code*Component Chart Name
0050906Phosphatidylserine Antibody IgG
0050907Phosphatidylserine Antibody IgM
0051591Phosphatidylcholine Ab, IgG
0051592Phosphatidylcholine Ab, IgM
0051602Phosphatidylethanolamine Antibody IgG
0051603Phosphatidylethanolamine Antibody IgM
0051608Phosphatidylinositol Antibody IgG
0051609Phosphatidylinositol Antibody IgM
2007604Phosphatidic Acid Antibody, IgM
2007606Phosphatidic Acid Antibody, IgG
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, contact interface support at interface.support@aruplab.com.
Cross References
  • APS non-criteria panel
  • Non-Criteria Antiphospholipid
  • non-criteria APS