Antiphospholipid Antibodies Extended Panel
2007609
Ordering Recommendation
Acceptable second-line test when antiphospholipid syndrome (APS) is strongly suspected and aPL criteria tests are negative.
Mnemonic
PHOS EXT
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Refer to individual components
Reported
1-8 days
N/A
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Seum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within two hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.6 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Urine or plasma. Contaminated, heat-inactivated, severely hemolyzed, grossly icteric, or severely lipemic specimens.  
Remarks
  
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
 
 
Test Number Components Reference Interval
 Phosphatidylserine Antibody, IgG Less than 11 U/mL
 Phosphatidylserine Antibody, IgM Less than  25 U/mL
 Phosphatidylethanolamine Antibody, IgG 0-​11 U/mL: Normal
12-​18 U/mL: Equivocal.  Suggest repeat testing in 4-​6 weeks or consider antibody testing for cardiolipin IgG and IgM, beta-​2 glycoprotein 1 IgG and IgM and lupus anticoagulant.
19 U/mL or greater: Positive
 Phosphatidylethanolamine Antibody, IgM 0-​11 U/mL: Normal
12-​18 U/mL: Equivocal.  Suggest repeat testing in 4-​6 weeks or consider antibody testing for cardiolipin IgG and IgM, beta-​2 glycoprotein 1 IgG and IgM and lupus anticoagulant.
19 U/mL or greater: Positive
 Phosphatidylinositol Antibody, IgG 0-​11 U/mL: Normal
12-​18 U/mL: Equivocal.  Suggest repeat testing in 4-​6 weeks or consider antibody testing for cardiolipin IgG and IgM, beta-​2 glycoprotein 1 IgG and IgM and lupus anticoagulant.
19 U/mL or greater: Positive
 Phosphatidylinositol Antibody, IgM 0-​11 U/mL: Normal
12-​18 U/mL: Equivocal.  Suggest repeat testing in 4-​6 weeks or consider antibody testing for cardiolipin IgG and IgM, beta-​2 glycoprotein 1 IgG and IgM and lupus anticoagulant.
19 U/mL or greater: Positive
 Phosphatidylcholine Antibody, IgG 0-​11 U/mL: Normal
12-​18 U/mL: Equivocal.  Suggest repeat testing in 4-​6 weeks or consider antibody testing for cardiolipin IgG and IgM, beta-​2 glycoprotein 1 IgG and IgM and lupus anticoagulant.
19 U/mL or greater: Positive
 Phosphatidylcholine Antibody, IgM 0-​11 U/mL: Normal
12-​18 U/mL: Equivocal.  Suggest repeat testing in 4-​6 weeks or consider antibody testing for cardiolipin IgG and IgM, beta-​2 glycoprotein 1 IgG and IgM and lupus anticoagulant.
19 U/mL or greater: Positive
 Phosphatidic Acid Antibody, IgG 
 
Reference Interval
0-​11 U/mL Normal
12-​18 U/mL Equivocal. Suggest repeat testing in 4-​6 weeks or consider antibody testing for cardiolipin IgG and IgM, beta-​2 glycoprotein 1 IgG and IgM and lupus anticoagulant.
19 U/mL or greater Positive
 Phosphatidic Acid Antibody, IgM 
 
Reference Interval
0-​11 U/mL Normal
12-​18 U/mL Equivocal. Suggest repeat testing in 4-​6 weeks or consider antibody testing for cardiolipin IgG and IgM, beta-​2 glycoprotein 1 IgG and IgM and lupus anticoagulant.
19 U/mL or greater Positive
Interpretive Data


See Compliance Statement D: www.aruplab.com/CS
Statement D: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
 
Note
 
CPT Code(s)
86148 x2, 83516 x8
Components
Component Test Code*Component Chart NameLOINC
0050906Phosphatidylserine Antibody IgG32032-5
0050907Phosphatidylserine Antibody IgM32033-3
0051591Phosphatidylcholine Ab, IgG 
0051592Phosphatidylcholine Ab, IgM 
0051602Phosphatidylethanolamine Antibody IgG13076-5
0051603Phosphatidylethanolamine Antibody IgM13077-3
0051608Phosphatidylinositol Antibody IgG13082-3
0051609Phosphatidylinositol Antibody IgM13083-1
2007604Phosphatidic Acid Antibody, IgM 
2007606Phosphatidic Acid Antibody, IgG 
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • APS non-criteria panel
  • Non-Criteria Antiphospholipid
  • non-criteria APS