Anti-C1q Antibody, IgG
Ordering Recommendation

Assess risk for lupus nephritis and global systemic lupus erythematosus (SLE) disease activity.

Semi-Quantitative Enzyme-Linked Immunosorbent Assay
1-15 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Serum separator tube. 
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Urine or plasma. Contaminated, heat-inactivated, severely hemolyzed or severely lipemic specimens. 
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles) 
Reference Interval
0-19 UnitsNegative
20-39 UnitsEquivocal
40 Units or greaterPositive

Interpretive Data
The presence of the anti-C1q IgG antibody may be associated with increased risk of lupus nephritis or with systemic lupus erythematosus (SLE) global activity. Anti-C1q antibodies are not specific for SLE; strong clinical correlation with disease is recommended.

Compliance Statement A: Analyte specific reagents (ASR) are used in many laboratory tests necessary for standard medical care and generally do not require U.S. Food and Drug Administration (FDA) approval or clearance. This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. This test should not be regarded as investigational or for research use.

Component Test Code*Component Chart NameLOINC
2007602Anti-C1q Antibody, IgG
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  • C1q IgG Ab