Non-Invasive Prenatal Testing for Fetal Aneuploidy (Panorama)
2007537
Ordering Recommendation
Screens for trisomy 13, 18, 21; Turner syndrome; and triploidy. Recommended for women at high risk for a fetal chromosomal aneuploidy. This includes women who 1) are 35 years or older at delivery, 2) have had a previous child with aneuploidy, 3) have a fetus with identified ultrasound anomalies associated with the above aneuploidies, or 4) have screened positive by maternal serum screening testing in the current pregnancy.
Mnemonic
NIPT ANEU
Methodology
Targeted sequencing with SNPs
Performed
Varies
Reported
12-14 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
 
Collect
Whole blood in Cell-Free DNA BCT Tube. All specimens must be collected using the NIPT ANEU kit (ARUP Supply #50223). Available online through eSupply or contacting ARUP Client Services at (800) 522-2787.
Required Specimen: Maternal specimens must be collected in 2 Cell-Free DNA BCT tubes.
Optional Specimen: Paternal specimens must be collected in buccal brush.  
Specimen Preparation
Transport 20 mL maternal blood in Cell-Free DNA BCT Tube (ARUP Supply #50223) and optional paternal buccal brush. (Min: 16 mL) Available online through eSupply or contacting ARUP Client Services at (800) 522-2787. A paternal specimen is requested but is not required for testing. The paternal specimen cannot be tested alone and must be provided along with the maternal blood. Do not send the buccal brush separately.  
Storage/Transport Temperature
Room temperature.  
Unacceptable Conditions
 
Remarks
Patient History and Informed Consent for Non-Invasive Prenatal Testing (NIPT) form required. Testing utilizes a single-nucleotide polymorphism (SNP)/ informatics-based approach to detect fetal copy number for the five chromosomes responsible for the majority of live-birth aneuploidies (chromosomes 13, 18, 21, X, Y, and triploidy). This is a screening test to help identify fetuses at risk for Down Syndrome, trisomy 18, trisomy 13 and Turner Syndrome. This test should not be considered diagnostic. It is recommended that any positive result should be confirmed by amniocentesis or CVS.  
Stability
Ambient: 5 days; Refrigerated: Unacceptable; Frozen: Unacceptable  
Reference Interval
By report
Interpretive Data
Refer to report.
Note
CPT Code(s)
(81479) or 81507*
*The 2014 AMA CPT manual contains the component CPT Codes and the new MAAA codes. Please direct any questions regarding CPT coding to the payer being billed.
Components
Component Test Code*Component Chart Name
2007538EER Non-Invasive Prenatal, Aneuploidy
2008381Trisomy 21
2008382Trisomy 18
2008383Trisomy 13
2008386Monosomy X
2008430Fetal Fraction
2008431Report Fetus Gender
2008830Triploidy/Vanishing Twin
2009259Result Summary
2009260Gestational Age (Weeks)
2010002Maternal Weight (Pounds)
2010003Gestational Age (Days)
2010004Fetus Gender
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Cross References
  • 45X
  • Ariosa
  • cell-free
  • cellfree
  • cffDNA
  • edward syndrome
  • Harmony
  • MaterniT21
  • Maternity21
  • Natera
  • NIPD
  • Panorama
  • patau syndrome
  • Sequenom
  • T13
  • T18
  • trisomy 21
  • Verifi
  • Verinata
Performed at Natera