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Tricyclic Antidepressants, Quantitative, Urine
2007515
Ordering Recommendation

Preferred test to follow-up presumptive results or for monitoring compliance. To optimize drug therapy, Tricyclic Antidepressants, Quantitative, Serum or Plasma (2007549) is preferred.

Mnemonic
TADQNT U
Methodology
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed
Mon, Wed, Fri
Reported
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Random urine. 
Specimen Preparation
Transfer 2 mL urine to ARUP Standard Transport Tube. (Min: 0.7 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
 
Remarks
 
Stability
Ambient: 1 week; Refrigerated: 11 days; Frozen: 2 weeks 
Reference Interval

Interpretive Data
Interpretive Data: Interpretive comments: Urine concentrations of tricyclic antidepressants do not correlate with signs or symptoms of therapy or toxicity.
Therapeutic ranges are not established.
100 ng/mL limit of quantification: Amitriptyline, Nortriptyline, Imipramine, Desipramine, Doxepin, Nordoxepin, Protriptyline
200 ng/mL limit of quantification: Clomipramine, Norclomipramine

Note
This test is used to quantitate the following tricyclic antidepressants: amitriptyline, clomipramine, desipramine, doxepin, imipramine, norclomipramine, nordoxepin, nortriptyline and protriptyline.
CPT Code(s)
80337 (Alt code: G0480)
Components
Component Test Code*Component Chart NameLOINC
2007516Amitriptyline, Quant, Urn16114-1
2007517Nortriptyline, Quant, Urn3875-2
2007518Amitriptyline/Nortriptyline Total, Urn10978-5
2007519Imipramine Quant, Urn3692-1
2007520Desipramine Quant, Urn3534-5
2007521Imipramine/Desipramine Total, Urn
2007522Doxepin Quant, Urn3581-6
2007523Nordoxepin Quant, Urn12386-9
2007524Doxepin/Nordoxepin Total, Urn19247-6
2007525Protriptyline Quant, Urn26978-7
2007526Clomipramine Quant, Urn3492-6
2007527Norclomipramine Quant, Urn18470-5
2007528Clomipramine/Norclomipramine Total, Urn
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Quantitative Antidepressant Drug Screen
  • TCA Screen
  • Tricyclic Screen