Thyroglobulin, Serum or Plasma with Reflex to LC-MS/MS or CIA
2006685
Ordering Recommendation
Recommended test for the surveillance of residual/recurrent thyroid cancer. Accurately measures thyroglobulin levels in serum or plasma.
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Mnemonic
THYROGRFX
Methodology
Quantitative Chemiluminescent Immunoassay/High Performance Chromatography-Tandem Mass
Performed
Sun-Sat
Reported
1-7 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
 
Collect
Serum separator tube. Also acceptable: Green (sodium or lithium heparin).  
Specimen Preparation
Transfer 3 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 1.5 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
EDTA or K2EDTA Plasma. Any fluid other than noted above. (See Thyroglobulin, Fine Needle Aspiration (FNA) (ARUP test code 0020753) for ordering alternate fluids).  
Remarks
 
Stability
After separation from cells: Ambient: 8 hours; Refrigerated: 48 hours; Frozen: 6 months  
Reference Interval
Test Number Components Reference Interval
Thyroglobulin Effective August 20, 2012
Age Reference Interval
6 months -​ 3 years 7.4-​48.7 ng/mL
4-​7 years 4.1-​40.5 ng/mL
8-​17 years 0.8-​29.4 ng/mL
18 years and older 1.3-​31.8 ng/mL
0050105Thyroglobulin Antibody Effective May 7, 2012

0.0-​4.0 IU/mL
2006550Thyroglobulin by LC-​MS/MS, Serum or Plasma
Age Reference Interval
6 months -​ 3 years 7.4 -​ 48.7 ng/mL
4 -​ 7 years 4.1 -​ 40.5 ng/mL
8 -​ 17 years 0.8 -​ 29.4 ng/mL
18 years and older 1.3 -​ 31.8 ng/mL
Interpretive Data
Specimens negative for thyroglobulin antibodies (TgAb) are tested for thyroglobulin (Tg) by chemiluminescent immunoassay (CIA) using the Beckman Coulter Access DxI method. Specimens with TgAb results above the upper reference limit are tested for Tg by high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). Results obtained with different test methods or kits cannot be used interchangeably. Tg results, regardless of concentration, should not be interpreted as absolute evidence for the presence or absence of papillary or follicular thyroid cancer. Tg testing is not recommended for use as a screening procedure to detect the presence of thyroid cancer in the general population.

Lower limit of detection for Thyroglobulin by LC-MS/MS is 0.5 ng/mL.
Note
The reflex testing method (CIA or LC-MS/MS) is determined by the TgAb result. Additional charges apply.
CPT Code(s)
86800; 84432
Components
Component Test Code*Component Chart Name
0050105Thyroglobulin Antibody
0070420Thyroglobulin, Serum or Plasma
2007078Thyroglobulin by LC-MS/MS, Serum/Plasma
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Cross References
  • Anti Thyroglobulin Antibody
  • HTG
  • Human Thyroglobulin
  • TATC
  • Tg
  • Thyroglobulin
  • Thyroglobulin Antibody
  • Thyroglobulin Assay for Thyroid Cancer
  • Thyroglobulin HTC