Drug Detection Panel by High-Resolution Time-of-Flight Mass Spectrometry, Umbilical Cord Tissue
Ordering Recommendation
Alternate test for postnatal meconium screening. Qualitative detection of drugs and drug metabolites to assess prenatal drug exposure.
Qualitative Liquid Chromatography/Time of Flight Mass Spectrometry/ Liquid Chromatography/Tandem Mass Spectrometry/Enzyme-Linked Immunosorbent Assay
1-3 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
at least 6 inches of umbilical cord (approximately the length of an adult hand).  
Specimen Preparation
Drain and discard any blood. Rinse the exterior of the cord segment with normal saline or sterile water. Pat the cord dry and place in container for transport.  
Storage/Transport Temperature
Unacceptable Conditions
Cords soaking in blood or other fluid.  Formalin fixed.  Tissue that is obviously decomposed.  
Ambient, 1 week; Refrigerated, 3 weeks; Frozen, 1 year  
Reference Interval
Effective October 7, 2013
Drugs covered and range of cutoff concentrations. Note that some drugs are identified based on the presence of unique drug metabolites not listed below.
Drugs/Drug Classes Range of Cutoff Concentrations
buprenorphine, codeine, fentanyl, heroin (6-​acetylmorphine), dihydrocodeine, hydrocodone, hydromorphone, meperidine, methadone, morphine, naloxone, naltrexone, oxycodone, oxymorphone, propoxyphene, tapentadol, tramadol
1-​10 ng/g
amphetamine, cocaine, methamphetamine, MDMA (Ecstasy), MDEA (Eve), MDA, phentermine
8 ng/g
alprazolam, butalbital, clonazepam, diazepam, flunitrazepam, flurazepam,lorazepam, midazolam, nitrazepam, nordiazepam, oxazepam, phenobarbital, secobarbital, temazepam, triazolam, zolpidem
5-​75 ng/g
Cannabinoids (11-​nor-​9-​carboxy-​THC) 150 pg/g
Phencyclidine (PCP) 4 ng/g
Interpretive Data
Methodology: Qualitative Liquid Chromatography/Time of Flight Mass Spectrometry/ Liquid Chromatography/Tandem Mass Spectrometry/Enzyme-Linked Immunosorbent Assay

Detection of drugs in umbilical cord tissue is intended to reflect maternal drug use during pregnancy. The pattern and frequency of drug(s) used by the mother cannot be determined by this test. A negative result does not exclude the possibility that a mother used drugs during pregnancy. Detection of drugs in umbilical cord tissue depends on extent of maternal drug use, as well as drug stability, unique characteristics of drug deposition in umbilical cord tissue, and the performance of the analytical method. Drugs administered during labor and delivery may be detected. Detection of drugs in umbilical cord tissue does not insinuate impairment and may not affect outcomes for the infant. Interpretive questions should be directed to the laboratory. Glucuronide metabolites are indicated as-G.

Results based on immunoassay detection that do not match clinical expectations should be interpreted with caution.

For medical purposes only; not valid for forensic use unless testing was performed within Chain of Custody process.

See Compliance Statement B:
Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
Absolute Minimum:  6 inches
CPT Code(s)
80304 x2; 80301; (Alt code: G0431)
Component Test Code*Component Chart NameLOINC
2006622Drug Detection Pan, TOF, Umbilical Cord 
2006626Buprenorphine (cutoff 2 ng/g) 
2006627Buprenorphine-G (cutoff 8 ng/g) 
2006628Codeine (cutoff 6 ng/g)40626-4
2006629Dihydrocodeine (cutoff 4 ng/g) 
2006630Fentanyl (cutoff 1 ng/g)61042-8
2006631Hydrocodone (cutoff 6 ng/g)32080-4
2006632Hydromorphone (cutoff 4 ng/g)32081-2
2006633Meperidine (cutoff 2 ng/g)32088-7
2006634Methadone (cutoff 10 ng/g)32093-7
2006635EDDP (cutoff 10 ng/g)41859-0
20066366-Acetylmorphine (cutoff 4 ng/g)32099-4
2006637Morphine (cutoff 4 ng/g)32100-0
2006638Naloxone (cutoff 8 ng/g) 
2006639Naltrexone (cutoff 8 ng/g) 
2006640Oxycodone (cutoff 4 ng/g)32101-8
2006641Oxymorphone (cutoff 4 ng/g) 
2006642Propoxyphene (cutoff 10 ng/g)43811-9
2006644Tapentadol (cutoff 2 ng/g) 
2006645Tramadol (cutoff 2 ng/g) 
2006646N-desmethyltramadol (cutoff 2 ng/g) 
2006647O-desmethyltramadol (cutoff 2 ng/g) 
2006648Amphetamine (cutoff 8 ng/g)29530-3
2006649Benzoylecgonine (8 ng/g)40609-0
2006650m-OH-Benzoylecgonine (cutoff 8 ng/g) 
2006652Cocaethylene (cutoff 8 ng/g) 
2006653Cocaine (cutoff 8 ng/g)40625-6
2006654MDMA- Ecstasy (cutoff 8 ng/g)40481-4
2006655MDA (cutoff 8 ng/g)61046-9
2006656MDEA- Eve (cutoff 8 ng/g)61049-3
2006657Methamphetamine (cutoff 8 ng/g)40381-6
2006658Phentermine (cutoff 8 ng/g) 
2006659Alprazolam (cutoff 5 ng/g)61038-6
2006660Alpha-OH-Alprazolam (cutoff 5 ng/g)61037-8
2006662Butalbital (cutoff 75 ng/g)32057-2
2006663Clonazepam (cutoff 5 ng/g)61039-4
20066647-Aminoclonazepam (cutoff 5 ng/g)61031-1
2006665Diazepam (cutoff 5 ng/g)61074-1
2006666Flunitrazepam (cutoff 5 ng/g)61079-0
20066677-Aminoflunitrazepam (cutoff 5 ng/g)61034-5
2006668Flurazepam (cutoff 5 ng/g)61080-8
2006669Desalkylflurazepam (cutoff 10 ng/g)61041-0
20066702-OH-Ethylflurazepam (cutoff 10 ng/g) 
2006671Lorazepam (cutoff 5 ng/g)61044-4
2006672Midazolam (cutoff 5 ng/g) 
2006673Alpha-OH-Midazolam (cutoff 5 ng/g) 
2006674Nitrazepam (cutoff 5 ng/g) 
2006675Nordiazepam (cutoff 5 ng/g)61051-9
2006676Oxazepam (cutoff 5 ng/g)61055-0
2006677Phenobarbital (cutoff 75 ng/g)32108-3
2006678Secobarbital (cutoff 75 ng/g)32111-7
2006679Temazepam (cutoff 5 ng/g)61061-8
2006680Triazolam (cutoff 5 ng/g)61093-1
2006681Alpha-OH-Triazolam (cutoff 5 ng/g) 
2006682Zolpidem (cutoff 10 ng/g) 
2006683Phencyclidine- PCP (cutoff 4 ng/g)32107-5
2008360Marijuana Metabolite (cutoff 150 pg/g)43834-1
2009199EER Drug Detection Pan, Umbilical Cord11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Drug Screen, Targeted, Serum or Plasma
  • Drugs of Abuse Panel, Meconium - Screen with Reflex to Confirmation/Quantitation