Drug Detection Panel by High-Resolution Time-of-Flight Mass Spectrometry, Umbilical Cord Tissue
2006621
Ordering Recommendation
Alternate test for postnatal meconium screening. Qualitative detection of drugs and drug metabolites to assess prenatal drug exposure.
Mnemonic
TOF SCR CD
Methodology
Qualitative Liquid Chromatography-Time of Flight Mass Spectrometry/Qualitative Enzyme-Linked Immunosorbent Assay
Performed
Sun-Sat
Reported
1-5 days
N/A
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
at least 6 inches of umbilical cord (approximately the length of an adult hand).  
Specimen Preparation
Drain and discard any blood. Rinse the exterior of the cord segment with normal saline or sterile water. Pat the cord dry and place in container for transport.  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Cords soaking in blood or other fluid. Tissue that is obviously decomposed.  
Remarks
  
Stability
Ambient, 1 week; Refrigerated, 3 weeks; Frozen, 1 year  
Reference Interval
Effective October 7, 2013
 
Drugs covered and range of cutoff concentrations. Note that some drugs are identified based on the presence of unique drug metabolites not listed below.
Drugs/Drug Classes Range of Cutoff Concentrations
Opioids:
buprenorphine, codeine, fentanyl, heroin (6-​acetylmorphine), dihydrocodeine, hydrocodone, hydromorphone, meperidine, methadone, morphine, naloxone, naltrexone, oxycodone, oxymorphone, propoxyphene, tapentadol, tramadol
1-​10 ng/g
Stimulants:
amphetamine, cocaine, methamphetamine, MDMA (Ecstasy), MDEA (Eve), MDA, phentermine
8 ng/g
Sedatives-​hypnotics:
alprazolam, butalbital, clonazepam, diazepam, flunitrazepam, flurazepam,lorazepam, midazolam, nitrazepam, nordiazepam, oxazepam, phenobarbital, secobarbital, temazepam, triazolam, zolpidem
5-​75 ng/g
Cannabinoids (11-​nor-​9-​carboxy-​THC) 150 pg/g
Phencyclidine (PCP) 4 ng/g
Interpretive Data
Methodology: Qualitative Liquid Chromatography-Time of Flight Mass Spectrometry and Enzyme-Linked Immunosorbent Assay

Detection of drugs in umbilical cord tissue is intended to reflect maternal drug use during pregnancy. The pattern and frequency of drug(s) used by the mother cannot be determined by this test. A negative result does not exclude the possibility that a mother used drugs during pregnancy. Detection of drugs in umbilical cord tissue depends on extent of maternal drug use, as well as drug stability, unique characteristics of drug deposition in umbilical cord tissue, and the performance of the analytical method. Drugs administered during labor and delivery may be detected. Detection of drugs in umbilical cord tissue does not insinuate impairment and may not affect outcomes for the infant. Interpretive questions should be directed to the laboratory. Glucuronide metabolites are indicated as-G.

For medical purposes only; not valid for forensic use unless testing was performed within Chain of Custody process.

See Compliance Statement B: www.aruplab.com/CS  
Note
Absolute Minimum:  6 inches
CPT Code(s)
80100 x2; 80101
Components
Component Test Code*Component Chart Name
2006622Drug Detection Pan, TOF, Umbilical Cord
2006623OPIOIDS, UMBILICAL CORD
2006624STIMULANTS, UMBILICAL CORD
2006625SEDATIVES-HYPNOTICS, UMBILICAL CORD
2006626Buprenorphine (cutoff 2 ng/g)
2006627Buprenorphine-G (cutoff 8 ng/g)
2006628Codeine (cutoff 6 ng/g)
2006629Dihydrocodeine (cutoff 4 ng/g)
2006630Fentanyl (cutoff 1 ng/g)
2006631Hydrocodone (cutoff 6 ng/g)
2006632Hydromorphone (cutoff 4 ng/g)
2006633Meperidine (cutoff 2 ng/g)
2006634Methadone (cutoff 10 ng/g)
2006635EDDP (cutoff 10 ng/g)
20066366-Acetylmorphine (cutoff 4 ng/g)
2006637Morphine (cutoff 4 ng/g)
2006638Naloxone (cutoff 8 ng/g)
2006639Naltrexone (cutoff 8 ng/g)
2006640Oxycodone (cutoff 4 ng/g)
2006641Oxymorphone (cutoff 4 ng/g)
2006642Propoxyphene (cutoff 10 ng/g)
2006644Tapentadol (cutoff 2 ng/g)
2006645Tramadol (cutoff 2 ng/g)
2006646N-desmethyltramadol (cutoff 2 ng/g)
2006647O-desmethyltramadol (cutoff 2 ng/g)
2006648Amphetamine (cutoff 8 ng/g)
2006649Benzoylecgonine (8 ng/g)
2006650m-OH-Benzoylecgonine (cutoff 8 ng/g)
2006652Cocaethylene (cutoff 8 ng/g)
2006653Cocaine (cutoff 8 ng/g)
2006654MDMA- Ecstasy (cutoff 8 ng/g)
2006655MDA (cutoff 8 ng/g)
2006656MDEA- Eve (cutoff 8 ng/g)
2006657Methamphetamine (cutoff 8 ng/g)
2006658Phentermine (cutoff 8 ng/g)
2006659Alprazolam (cutoff 5 ng/g)
2006660Alpha-OH-Alprazolam (cutoff 5 ng/g)
2006662Butalbital (cutoff 75 ng/g)
2006663Clonazepam (cutoff 5 ng/g)
20066647-Aminoclonazepam (cutoff 5 ng/g)
2006665Diazepam (cutoff 5 ng/g)
2006666Flunitrazepam (cutoff 5 ng/g)
20066677-Aminoflunitrazepam (cutoff 5 ng/g)
2006668Flurazepam (cutoff 5 ng/g)
2006669Desalkylflurazepam (cutoff 10 ng/g)
20066702-OH-Ethylflurazepam (cutoff 10 ng/g)
2006671Lorazepam (cutoff 5 ng/g)
2006672Midazolam (cutoff 5 ng/g)
2006673Alpha-OH-Midazolam (cutoff 5 ng/g)
2006674Nitrazepam (cutoff 5 ng/g)
2006675Nordiazepam (cutoff 5 ng/g)
2006676Oxazepam (cutoff 5 ng/g)
2006677Phenobarbital (cutoff 75 ng/g)
2006678Secobarbital (cutoff 75 ng/g)
2006679Temazepam (cutoff 5 ng/g)
2006680Triazolam (cutoff 5 ng/g)
2006681Alpha-OH-Triazolam (cutoff 5 ng/g)
2006682Zolpidem (cutoff 10 ng/g)
2006683Phencyclidine- PCP (cutoff 4 ng/g)
2006684PHENCYCLIDINE, UMBILICAL CORD
2008359OTHER, IMMUNOASSAY, UMBILICAL CORD
2008360Marijuana Metabolite (cutoff 150 pg/g)
2009199EER Drug Detection Pan, Umbilical Cord
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Drug Screen, Targeted, Serum or Plasma
  • Drugs of Abuse Panel, Meconium - Screen with Reflex to Confirmation/Quantitation