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Phosphatidylserine Antibodies, IgG and IgM
2006495
Ordering Recommendation

Preferred second-line test for strong suspicion of seronegative antiphospholipid syndrome. Order incrementally or concurrently with other noncriteria antiphospholipid antibody tests.

Mnemonic
PHOSSER GM
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Sun, Tue, Wed, Fri, Sat
Reported
1-3 days
N/A
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum separator tube 
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL) 
Storage/Transport Temperature
Refrigerated 
Unacceptable Conditions
Heat-inactivated, contaminated, grossly icteric, grossly hemolyzed, or severely lipemic specimens 
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles) 
Reference Interval
Test Number
Components
Reference Interval
 Phosphatidylserine Antibody IgGLess than 11 U/mL
 Phosphatidylserine Antibody IgMLess than  25 U/mL

Interpretive Data
IgG and/or IgM antibodies to phosphatidylserine (aPS) may be associated with a positive test for anti-cardiolipin autoantibodies (aCL) and risk for obstetric antiphospholipid syndrome (APS). Strong clinical correlation is recommended in the absence of lupus anticoagulant, IgG and/or IgM cardiolipin and/or beta2 glycoprotein antibodies.

Isolated presence of IgM or IgG antibodies to aPS may have questionable clinical significance for APS and/or SLE.

If results are positive, repeat testing with two or more specimens drawn at least 12 weeks apart to demonstrate persistence of antibodies.

Results should not be used alone for diagnosis and must be interpreted in light of APS-specific clinical manifestations and/or other criteria phospholipid antibody tests.

Note
CPT Code(s)
86148x2
Components
Component Test Code*Component Chart NameLOINC
0050906Phosphatidylserine Antibody IgG32032-5
0050907Phosphatidylserine Antibody IgM32033-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Anti-Phosphatidylserine
  • Anti-Phosphatidylserine (aPS)
  • Antiphosphatidylserine
  • aPS Antibodies IgG, IgM, IgA