Preferred reflex panel for the workup of suspected vasculitis. For patients with a history of vasculitis, refer to Anti-Neutrophil Cytoplasmic Antibody with Reflex to Titer and MPO/PR-3 Antibodies (2002068).
For evaluation of autoimmune liver disease, use in conjunction with Autoimmune Liver Disease Evaluation with Reflex to Smooth Muscle Antibody (SMA), IgG by IFA (2007210).
- Patient Preparation
- Collect
- Serum separator tube.
- Specimen Preparation
- Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)
- Storage/Transport Temperature
- Refrigerated.
- Unacceptable Conditions
- CSF, plasma, urine, or other body fluids. Contaminated, hemolyzed, or severely lipemic specimens.
- Remarks
- Stability
- After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Test Number | Components | Reference Interval | ||||||
---|---|---|---|---|---|---|---|---|
  | Anti-Neutrophil Cytoplasmic Ab, IgG | < 1:20: Not significant | ||||||
  | Myeloperox Antibodies, IgG |
| ||||||
  | Serine Protease3, IgG |
|
ANCA IFA is simultaneously tested on ethanol- and formalin-fixed slides to allow differentiation of C- and P-ANCA patterns.
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0050526 | Myeloperox Antibodies, IgG | 6969-0 |
0050527 | Serine Protease3, IgG | 6968-2 |
0050811 | Anti-Neutrophil Cytoplasmic Ab, IgG | 29967-7 |
- (Perinuclear Antineutrophil Cytoplasmic Antibody
- ANCA
- ANCA Reflex
- Anti-Neutrophil Cytoplasmic Ab Test
- Anti-Neutrophil Cytoplasmic Antibodies Panel, IgG
- Anticytoplasmic Antibody
- Antineutrophil Cytoplasmic Antibodies (ACPA)
- Autoantibodies to Proteinase 3
- c-ANCA
- Cytoplasmic Neutrophil Antibodies
- MPO)
- P-ANCA
- pANCA
- PR3
- Proteinase 3