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IDH1 and IDH2 Mutation Analysis, exon 4
2006444
Ordering Recommendation

Detect IDH1 and IDH2 mutations in whole blood or bone marrow. May have prognostic significance in patients with hematologic malignancies, depending on the clinical and genetic context. For FFPE tissues, use IDH1 and IDH2 Mutation Analysis, Exon 4, Formalin-Fixed, Paraffin-Embedded (FFPE) Tissue (2014188).

Mnemonic
IDH1-2
Methodology
Polymerase Chain Reaction/Sequencing
Performed
Sun, Tue, Thur
Reported
12-14 days
N/A
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Lavender (EDTA), or bone marrow (EDTA). 
Specimen Preparation
Whole Blood: Transport 5 mL whole blood. (Min: 1 mL)
Bone Marrow: Transport 3 mL bone marrow. (Min: 1 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Serum or plasma. Specimens collected in anticoagulants other than EDTA. Clotted or grossly hemolyzed specimens. 
Remarks
 
Stability
Ambient: 24 hours; Refrigerated: 5 days; Frozen: Unacceptable 
Reference Interval
Interpretive Data
Refer to report.

Compliance Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Components
Component Test Code*Component Chart NameLOINC
2006445IDH1 and IDH2 Mutation Results35474-6
2006510IDH 1-2 Source31208-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • IDH1
  • IDH1 SNP
  • IDH2
  • Isocitrate dehydrogenase (IDH) 1 and 2
  • Isocitrate Dehydrogenase 1
  • Isocitrate Dehydrogenase 2
  • NADP+